Dexter's Laboratory: Chess Challenge is a board game-style video game developed by Virtucraft and published by BAM! Entertainment for the Game Boy Advance. The game is based on the Cartoon Network animated series Dexter's Laboratory as well as the game Battle Chess. It was released in North America on October 29, 2002, alongside The Powerpuff Girls: Him and Seek.
The player uses one of four chess sets (Dexter's, Dee Dee's, Mandark's, or Major Glory's) featuring Dexter's Laboratory-themed pieces in the traditional game of chess. Piece captures are accompanied by animated scenes depicting the defeat of the captured piece. There is also a puzzle mode, which when completed unlocks the hardest game difficulty.
A versus mode allows two players to swap a single Game Boy Advance back and forth or play against each other on two separate Game Boy Advances with two copies of the game. The game's difficulty is geared towards younger players.
Joel Santo Domingo of PCMag.com gave the game a 3/5 "good" rating, calling it "basically the same novelty" as Battle Chess.