Dexter's rival, Mandark, has broken into Dexter's laboratory and is attempting to destroy it by reprogramming the lab's Computer to block Dexter from entering. The protagonist, Dexter, must use his inventions and his wits to defeat his archenemy before his laboratory succumbs to Mandark's destruction.
Based on the television series, the game is set in both Dexter's house and laboratory. The game's single-player is divided into four levels with each contain puzzling challenges that feature various inventions Dexter has created. Each level contains two minigames which the player must find and complete to advance to the next level. The game features a total of eight minigames which can be played alone or in a two-player mode, with one person playing as Dexter and the other as Mandark. The minigames include Dee Dee's Dance Off, Cootie Call, Up N Atom, and Dexter Dodge Ball. In each level, players can also unlock a different improved invention by collecting four blueprint pieces hidden in the level. The improved inventions make it easier to complete the minigames in that level.
Based on four reviews, the game received a score of 62% on Metacritic, corresponding to a "mixed or average" rating.Allgame's reviewer Jennifer Beam appreciated the game's animated cutscenes and said they were "like watching the show itself and the characters are depicted relatively well." Beam also praised the game's voice work for Dexter, performed by Candi Milo who also does the voice for Dexter on the television series. Troy Oxford of The Atlanta Journal-Constitution said the mini-games make the title a success.PSIllustrated's Stephen Triche also praised the game's graphics, but he was dissatisfied with the game on the whole and found the minigames to be dull: "I get the feeling Red-Lemon Studios used a young target audience as an excuse for making a game that I've quite simply found lacking."