Amine oxidase

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Ribbon representation of human diamine oxidase.[1]
amiloride binding protein 1 (amine oxidase (copper-containing))
Symbol ABP1
Entrez 26
OMIM 104610
RefSeq NM_001091
UniProt P19801
Other data
EC number
Locus Chr. 7 q34-qter

Amine oxidase (also known as histaminase) is an enzyme involved in the metabolism, oxidation, and inactivation of histamine within the digestive tract.


External links[edit]

  • García-Martín, E; Ayuso, P; Martínez, C; Blanca, M; Agúndez, JA (May 2009). "Histamine pharmacogenomics". Pharmacogenomics 10 (5): 867–83. doi:10.2217/pgs.09.26. PMID 19450133. 
  • García-Martín, E; Ayuso, P; Martínez, C; Agúndez, JA (Nov 2007). "Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals". Clin Biochem 40 (16-17): 1339–41. doi:10.1016/j.clinbiochem.2007.07.019. PMID 17826755. 
  • Ayuso, P; García-Martín, E; Martínez, C; Agúndez, JA (Sep 2007). "Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity". Pharmacogenet Genomics 17 (9): 687–93. doi:10.1097/FPC.0b013e328012b8e4. PMID 17700358. 
  • García-Martín, E; García-Menaya, J; Sánchez, B; Martínez, C; Rosendo, R; Agúndez, JA (Aug 2007). "Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis". Clin Exp Allergy 37 (8): 1175–82. doi:10.1111/j.1365-2222.2007.02769.x. PMID 17651147. 
  • García-Martin, E; Mendoza, JL; Martínez, C; Taxonera, C; Urcelay, E; Ladero, JM; de la Concha, EG; Díaz-Rubio, M; Agúndez, JA (Jan 2006). "Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene". World J Gastroenterol 12 (4): 615–20. PMID 16489678. 
  • Amine Oxidase (Copper-Containing) at the US National Library of Medicine Medical Subject Headings (MeSH)


  1. ^ PDB 3HI7; McGrath AP, Hilmer KM, Collyer CA, Shepard EM, Elmore BO, Brown DE, Dooley DM, Guss JM (2009). "Structure and inhibition of human diamine oxidase". Biochemistry 36 (41): 9810–9822. doi:10.1021/bi9014192. PMC 2791411. PMID 19764817. ; rendered with PyMOL
  2. ^ Agúndez, JA; Ayuso, P; Cornejo-García, JA; Blanca, M; Torres, MJ; Doña, I; Salas, M; Blanca-López, N; Canto, G; Rondon, C; Campo, P; Laguna, JJ; Fernández, J; Martínez, C; García-Martín, E (2012). "The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs". PLOS ONE 7 (11): e47571. doi:10.1371/journal.pone.0047571. PMID 23152756.