Diaminopyrimidine
From Wikipedia, the free encyclopedia
Diaminopyrimidines are a class of organic chemical compounds that include two amine groups on a pyrimidine ring.
They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritrexim [1] and the antibiotics Iclaprim and trimethoprim).
Some have been patented as anti-cancer drugs.[2]
[edit] See also
[edit] References
- ^ http://aac.asm.org/cgi/content/full/45/12/3293 "Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2001
- ^ http://www.wipo.int/pctdb/en/wo.jsp?IA=GB1998000111&DISPLAY=DESC
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