English created and produced the short-lived situation comedyFoley Square, starring Margaret Colin, which aired on CBS from December 1985 to April 1986. In 1986, she became the executive producer of the Pam Dawber sitcom My Sister Sam, which ran for two seasons on CBS and co-starred Rebecca Schaeffer. In 1988, she created the CBS television series Murphy Brown, for which she won one Emmy for Outstanding Writing in a Comedy Series and two for Outstanding Comedy Series. In 1992, English stirred up controversy when the title character of Murphy Brown decided to have a child out of wedlock. Vice President Dan Quayle strongly voiced his disapproval of this decision, opining that English was mocking the importance of a father's role in the rearing of a child. Quayle was also joined in his protest by English's brother Richard English, who is a Baptist preacher in Western New York. Several years later, President Bill Clinton stated that Quayle made some valid points in his remarks.
English later created the comedy series Love & War, first with Susan Dey and then with Annie Potts, which ran from 1992 to 1995 on CBS. Other series included "Double Rush" for CBS, "The Louis Show" for CBS, "Ink" for CBS, and "Living in Captivity" for Fox.