Cinchocaine

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Cinchocaine
Cinchocaine.svg
Cinchocaine 3D ball-and-stick.png
Systematic (IUPAC) name
2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Routes topical, intravenous (equine euthanasia)
Identifiers
CAS number 85-79-0 YesY
ATC code C05AD04 D04AB02 N01BB06 S01HA06 S02DA04
PubChem CID 3025
DrugBank DB00527
ChemSpider 2917 YesY
UNII L6JW2TJG99 YesY
KEGG D00733 YesY
ChEBI CHEBI:247956 YesY
ChEMBL CHEMBL1086 YesY
Chemical data
Formula C20H29N3O2 
Mol. mass 343.463 g/mol
 YesY (what is this?)  (verify)

Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia.[1][2] It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.

Medical use[edit]

Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.

Physical properties[edit]

Cinchocaine is relatively insoluble in alkaline aquatic solutions.

See also[edit]

References[edit]

  1. ^ Martindale, The Extra Pharmacopoeia, 30th ed, p1006
  2. ^ Dibucaine

Further reading[edit]

  • Abdel-Ghani N, Youssef A, Awady M (2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry.". Farmaco 60 (5): 419–24. doi:10.1016/j.farmac.2005.03.001. PMID 15910814. 
  • Souto-Padron T, Lima AP, de Oliveira Ribeiro R. (2006). "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi.". Parasitol Res 99 (4): 317. doi:10.1007/s00436-006-0192-1. PMID 16612626. 
  • Nounou M, El-Khordagui L, Khalafallah N (2005). "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles.". Acta Pol Pharm 62 (5): 369–79. PMID 16459486. 
  • Aroti,A.;Leontidis, E. (2001). "Simultaneous Determination of the Ionization Constant and the Solubility of Sparingly Soluble Drug Substances. A Physical Chemistry Experiment .". Journal of Chemical Education 78 (6): 786–788. doi:10.1021/ed078p786.