Diclofenamide

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Diclofenamide
Skeletal formula of diclofenamide
Space-filling model of diclofenamide
Systematic (IUPAC) name
4,5-dichlorobenzene-1,3-disulfonamide
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a601233
Legal status ?
Pharmacokinetic data
Protein binding 55%
Identifiers
CAS number 120-97-8 YesY
ATC code S01EC02
PubChem CID 3038
DrugBank DB01144
ChemSpider 2930 YesY
UNII VVJ6673MHY YesY
KEGG D00518 YesY
ChEBI CHEBI:101085 YesY
ChEMBL CHEMBL17 YesY
Chemical data
Formula C6H6Cl2N2O4S2 
Mol. mass 305.16 g/mol
 N (what is this?)  (verify)

Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class.

Uses[edit]

Diclofenamide is used to treat glaucoma[1][2] and therapy-resistant epilepsy.[3]

References[edit]

  1. ^ International Drug Names: Diclofenamide
  2. ^ Kanski, J. J. (1968). "Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors". The British journal of ophthalmology 52 (8): 642–643. doi:10.1136/bjo.52.8.642. PMC 506660. PMID 5724852.  edit
  3. ^ Rucquoy, M.; Sorel, L. (1978). "Diclofenamide in the treatment of therapy-resistant epilepsy". Acta neurologica Belgica 78 (3): 174–182. PMID 352085.  edit
  • Tawil R, McDermott M, Brown R, Shapiro B, Ptacek L, McManis P, Dalakas M, Spector S, Mendell J, Hahn A, Griggs R (2000). "Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis.". Ann Neurol 47 (1): 46–53. doi:10.1002/1531-8249(200001)47:1<46::AID-ANA9>3.0.CO;2-H. PMID 10632100. 
  • Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S (1991). "[Diclofenamide Reference Standard (Control 891) of National Institute of Hygienic Sciences]". Eisei Shikenjo Hokoku 109 (109): 148–50. PMID 1364383.