Calderón participated in LDU Quito's campaign in the Copa Libertadores 2008. He made great defensive displays against many of Liga's opponents. However, he sustained an injury during the Round of 16 and was replaced by Renán Calle for the rest of the tournament. His team became the first Ecuadorian team to win the Copa Libertadores.
Calderón again became a regular starter during Liga's campaign in the 2008 FIFA Club World Cup. He played both games against Pachuca and Manchester United. Although Liga was able to defeat Pachuca 2-0 in the semifinals, they lost the final to Manchester United, 1-0. He and the rest of his team had a good, solid performance throughout the tournament. He was loaned to the Colorado Rapids in advance of the 2013 season, although he missed much of the season following knee surgery.