Diethylcarbamazine

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Diethylcarbamazine
Diethylcarbamazine.svg
Systematic (IUPAC) name
N,N-diethyl-4-methylpiperazine-1-carboxamide
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Legal status Legal
Pharmacokinetic data
Half-life .
Identifiers
CAS number 90-89-1 YesY
ATC code P02CB02 QP52AH02
PubChem CID 3052
DrugBank DB00711
ChemSpider 2944 YesY
UNII V867Q8X3ZD YesY
KEGG D07825 YesY
ChEMBL CHEMBL684 YesY
Chemical data
Formula C10H21N3O 
Mol. mass 199.293 g/mol
 YesY (what is this?)  (verify)

Diethylcarbamazine Citrate (DEC) (N, N-diethyl-4-methyl-1-piperazine carboxamide dihydrogen citrate) is a synthetic derivative of piperazine, used as an anthelmintic drug used in the treatment of filariasis in humans, dogs and cats. Discovery was attributed to Yellapragada Subbarow.

DEC is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[1]

Medical uses[edit]

DEC is indicated for treatment of individual patients with certain filarial diseases. These diseases include: lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori; tropical pulmonary eosinophilia, and loiasis.

In cases of onchocerciasis, another common filarial parasite, the drug is not used. This is because of the intense and unbearable itching associated with the dead subcutaneous parasites.

DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis. DEC is also used in the prevention of dog heartworm Dirofilaria immitis.

Now WHO prescribes DEC to patients who are susceptible to filariasis by preventive regimen in endemic areas.

Contraindications are Previous history of heart problems, Gastrointestinal problems, allergic patients

Mechanism[edit]

DEC is an inhibitor of arachidonic acid metabolism in filarial microfilaria. This makes the microfilaria more susceptible to immune attack. However, DEC is not directly toxic to the filarial microfilaria [2].

Trade names[edit]

  • Hetrazan
  • Carbilazine
  • Caricide
  • Cypip
  • Ethodryl
  • Notézine
  • Spatonin
  • Filaribits
  • Banocide Forte
  • Eofil

references[edit]

  1. ^ "WHO Model List of EssentialMedicines". World Health Organization. October 2013. Retrieved 22 April 2014. 
  2. ^ El-Shahawi GA et al. Setaria equina: in vivo effect of diethylcarbamazine citrate on microfilariae in albino rats. Exp Parasitol. 2010 Dec;126(4):603-10 from http://www.ncbi.nlm.nih.gov/pubmed/20599991 accessed on 11Jul2014