Diethylcathinone

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Diethylcathinone
Systematic (IUPAC) name
2-diethylamino-1-phenyl-propan-1-one
Identifiers
CAS number 134-80-5
ATC code A08AA03
PubChem 7029
DrugBank 7029
ChemSpider 6762
Chemical data
Formula C13H19NO
Mol. mass 205.30 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B

Legal status

Schedule IV(US)

Routes Oral

Diethylcathinone (Tenuate, Anorex, Linea, Nobesine, Prefamone, Regenon, Tepanil), also known as diethylpropion or amfepramone, is a stimulant drug of the phenethylamine, amphetamine, and cathinone chemical classes that is used as an appetite suppressant.

Contents

[edit] Pharmacology

Diethylcathinone itself lacks any affinity for the monoamine transporters and instead functions as a prodrug to ethcathinone.[1] Ethcathinone (and therefore diethylcathinone as well) is a very weak dopaminergic and serotonergic, and is approximately 10x and 20x stronger on norepinephrine in comparison, respectively.[1] As a result, ethcathinone and diethylcathinone can essentially be considered selective norepinephrine releasing agents (NRAs).

[edit] Neurotoxicity

Diethylcathinone has been found to be neurotoxic in that it causes long-term depletions of serotonin similarly to methamphetamine and MDMA ("Ecstasy").[2]

[edit] Legality

Diethylcathinone is classified as a Schedule IV controlled substance in the United States.

[edit] See also

[edit] References

  1. ^ a b Rothman RB, Baumann MH (2006). "Therapeutic potential of monoamine transporter substrates". Current Topics in Medicinal Chemistry 6 (17): 1845–59. PMID 17017961. http://www.bentham-direct.org/pages/content.php?CTMC/2006/00000006/00000017/0004R.SGM. 
  2. ^ Kleven et al., unpublished data Methamphetamine-induced Neurotoxicity: Structure Activity Relationships Annals of the New York Academy of Sciences Volume 654, pg 292–301



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