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Digitonin CASCC.png
CAS number 11024-24-1 YesY
PubChem 25444
ChemSpider 23753 YesY
EC-number 234-255-6
KEGG C00765 N
Jmol-3D images Image 1
Molecular formula C56H92O29
Molar mass 1,229.31 g mol−1
Chiral rotation [α]D −47 to −49° (10 g/100 ml 75% acetic acid at 25 °C)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. Used as a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.

Digitonin is sometimes confused with the cardiac drug digoxin (sometimes also called digitalis or digitoxin), but has no heart-related effects.

Physical, chemical and biological properties[edit]

Critical micelle concentration = < 0.5 mM
Average micellar weight = 70000
Appearance = White to off-white powder
Boiling Point/Melting Point = 230 to 240 °C
Aggregation number = 60
Rat-LD50 = 4 mg/kg body weight (IVN), 51 mg/kg body weight (ORAL)