Digoxin Immune Fab

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Digoxin Immune Fab
Systematic (IUPAC) name
Anti-digoxin antibody fragment
Clinical data
AHFS/Drugs.com Consumer Drug Information
Pregnancy cat. C (US)
Legal status ?
Routes IV infusion, injection
Pharmacokinetic data
Half-life 15 hours for DigiFab, 23 hours for Digibind
Excretion Renal
Identifiers
ATC code V03AB24
DrugBank DB00076
ChEMBL CHEMBL1201588 N
Chemical data
Formula C6394H9908N1698O2011S58 
Mol. mass 144602.257 g/mol
 N (what is this?)  (verify)

Digoxin immune fab (ovine) is the generic name for an antidote for overdose of digitalis.[1] It is made from immunoglobulin fragments from sheep that have already been immunized with a digoxin derivative, digoxindicarboxymethoxylamine. Its brand names include Digibind ( GlaxoSmithKline) and DigiFab (BTG plc).

Digoxin immune fab used to treat digoxin toxicity

Pharmacology[edit]

It works by binding to the digoxin, rendering it unable to bind to its action sites on target cells. The complexes accumulate in the blood and are expelled by the kidney.

Contraindications[edit]

Although no contraindications have been noted, the patient must be closely monitored for anaphylactic shock, and anyone allergic to sheep protein, papain, bromelain, or papaya extracts (papain is used to cleave the antibody into Fab and Fc fragments) should not use ovine digoxin immune fab. Because it is relatively new, no drug interaction studies have been performed yet.

References[edit]

  1. ^ DiDomenico RJ, Walton SM, Sanoski CA, Bauman JL (2000). "Analysis of the use of digoxin immune fab for the treatment of non-life-threatening digoxin toxicity". J. Cardiovasc. Pharmacol. Ther. 5 (2): 77–85. doi:10.1053/XV.2000.5590. PMID 11150387. 

External links[edit]