Dihydrodeoxycorticosterone

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Dihydrodeoxycorticosterone
Dihydrodeoxycorticosterone.svg
Identifiers
CAS number 298-36-2
PubChem 6451493
ChemSpider 4953958
Jmol-3D images Image 1
Properties
Molecular formula C21H32O3
Molar mass 332.48 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Dihydrodeoxycorticosterone (abbreviated as DHDOC; 21-hydroxy-5α-pregnan-20-one) is an endogenous progestogen and neurosteroid.[1] It is synthesized from the adrenal hormone deoxycorticosterone (DOC) by the enzyme 5α-reductase type I.[1] DHDOC is an agonist of the progesterone receptor, as well as a positive allosteric modulator of the GABAA receptor, and is known to have anticonvulsant effects.[1][2]

See also[edit]

References[edit]

  1. ^ a b c Reddy DS, Rogawski MA (May 2002). "Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility". J. Neurosci. 22 (9): 3795–805. PMID 11978855. 
  2. ^ Edwards HE, Vimal S, Burnham WM (December 2005). "The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses". Epilepsia 46 (12): 1888–97. doi:10.1111/j.1528-1167.2005.00295.x. PMID 16393154.