Dihydrodipicolinate reductase

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dihydrodipicolinate reductase
EC number
CAS number 9055-46-3
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dihydrodipicolinate reductase (EC is an enzyme that catalyzes the chemical reaction

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ \rightleftharpoons 2,3-dihydrodipicolinate + NAD(P)H + H+

The 3 substrates of this enzyme are (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, NAD+, and NADP+, whereas its 4 products are 2,3-dihydrodipicolinate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ oxidoreductase. Other names in common use include dihydrodipicolinic acid reductase, and 2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase. This enzyme participates in lysine biosynthesis.

Structural studies[edit]

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 1ARZ, 1C3V, 1DIH, 1DRU, 1DRV, 1DRW, 1P9L, 1VM6, 1YL5, 1YL6, and 1YL7.


  • Farkas W, Gilvarg C (1965). "The reduction step in diaminopimelic acid biosynthesis". J. Biol. Chem. 240 (12): 4717–22. PMID 4378965. 
  • Tamir H (1971). "Dihydrodipicolinic acid reductase (Escherichia coli)". Methods Enzymol. 17B: 134–139. doi:10.1016/0076-6879(71)17030-9.