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Dihydropteroic acid.svg
CAS number 2134-76-1 N
PubChem 170
ChemSpider 165 YesY
KEGG C00921 N
Beilstein Reference 1226443
Jmol-3D images Image 1
Image 2
Molecular formula C14H14N6O3
Molar mass 314.3 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Dihydropteroate is a pterin created from para-aminobenzoic acid (PABA) by the enzyme dihydropteroate synthase. It is an important intermediate in folate synthesis.

Tetrahydrofolate synthesis pathway

Bacteriostatic agents, such as sulfonamides, target dihydropteroate synthetase. The effect of dihydropteroate synthetase inhibition is comparable to that of dihydrofolate reductase inhibition by trimethoprim, another bacteriostatic agent. Together these two drugs - trimethoprim-sulfamethoxazole [TMP-SMX] - are commonly used to treat recurrent urinary tract, Shigella, Salmonella, and Pneumocystis jivoreci infections.

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