Dihydropyridine

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Dihydropyridine
Skeletal formula of dihydropyridine
Identifiers
CAS number 3337-17-5 YesY
PubChem 104822
ChemSpider 94619 YesY
MeSH 1,4-dihydropyridine
Jmol-3D images Image 1
Properties
Molecular formula C
5
H
7
N
Molar mass 81.1158 g mol-1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

Dihydropyridine is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as Verapamil) which have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure.

Class members[edit]

The L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries): These are derivatives of Dihydropyridine.

Name Image Brand name Discovered
Amlodipine
Amlodipine.png
Norvasc, Istin
Aranidipine
Aranidipine.svg
Azelnidipine
Azelnidipine.png
Barnidipine
Barnidipine.png
Benidipine
Benidipine.png
Cilnidipine
Cilnidipine.svg
Clevidipine
Clevidipine.png
Cronidipine
Darodipine
Darodipine.png
Dexniguldipine
Efonidipine
Efonidipine.png
Elnadipine
Elgodipine
Felodipine
Felodipine.png
Renedil, Plendil
Flordipine
Furnidipine
Iganidipine
Isradipine
Isradipine.png
Lacidipine
Lacidipine.png
Lemildipine
Lercanidipine
Lercanidipine.svg
Zanidip
Manidipine
Manidipine.svg
Mesuldipine
Nicardipine
Nicardipine.svg
Cardene
Nifedipine
Nifedipine.svg
Adalat, Nifedical, Procardia
Niguldipine
Niguldipine.png
Nimodipine
Nimodipine.png
Nimotop
Niludipine
Nilvadipine
Nilvapidine.png
Nisoldipine
Nisoldipine.svg
Sular
Nitrendipine
Nitrendipine.svg
Olradipine
Oxodipine
Oxodipine.png
Palonidipine
Pranidipine
Pranidipine.png
Sagandipine
Sornidipine
Teludipine
Tiamdipine
Trombodipine
Watanidipine

See also[edit]

References[edit]

  1. ^ "1,4-dihydropyridine - Compound Summary". Pubchem Compound. USA: National Center for Biotechnology Information. 27 March 2005. Identification and Related Records. Retrieved 1 November 2011. 

External links[edit]