Dihydropyrimidine dehydrogenase

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dihydropyrimidine dehydrogenase
Identifiers
Symbol DPYD
Entrez 1806
HUGO 3012
OMIM 274270
RefSeq NM_000110
Other data
EC number 1.3.1.2
Locus Chr. 1 p22

Dihydropyrimidine dehydrogenase (DPD) is an enzyme that is involved in pyrimidine degradation. It is the initial and rate-limiting step in pyrimidine catabolism. It catalyzes the reduction of uracil and thymine. It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and Tegafur-uracil.

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