Dimemorfan

Dimemorfan
Systematic (IUPAC) name
	(9α,13α,14α)-3,17-dimethylmorphinan
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	36309-01-0
ATC code	R05DA11
PubChem	CID 3037918
ChemSpider	16735785
UNII	623OAC38YU
KEGG	D07848
Chemical data
Formula	C18H25N
Mol. mass	255.398 g/mol
	SMILES Cc3ccc4C[C@@H]1N(C)CC[C@]2(CCCC[C@H]12)c4c3;
	InChI InChI=1S/C18H25N/c1-13-6-7-14-12-17-15-5-3-4-8-18(15,16(14)11-13)9-10-19(17)2/h6-7,11,15,17H,3-5,8-10,12H2,1-2H3/t15-,17+,18+/m1/s1 ; Key:KBEZZLAAKIIPFK-NJAFHUGGSA-N ;
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Dimemorfan is an antitussive or cough suppressant which acts as a sigma receptor agonist.^[1]^[2] It is an analogue of dextromethorphan and dextrorphan, but lacks significant NMDA receptor antagonistic action and dissociative effects, thereby having reduced abuse potential and adverse effects in comparison.^[3]

References[edit]

^ Wang, H. H.; Chien, J. W.; Chou, Y. C.; Liao, J. F.; Chen, C. F. (2003). "Anti-amnesic effect of dimemorfan in mice". British Journal of Pharmacology 138 (5): 941–949. doi:10.1038/sj.bjp.0705117. PMC 1573728. PMID 12642396. edit
^ Shin, E. J.; Nah, S. Y.; Kim, W. K.; Ko, K. H.; Jhoo, W. K.; Lim, Y. K.; Cha, J. Y.; Chen, C. F. et al. (2005). "The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via σ1 receptor activation: Comparison with the effects of dextromethorphan". British Journal of Pharmacology 144 (7): 908–918. doi:10.1038/sj.bjp.0705998. PMC 1576070. PMID 15723099. |displayauthors= suggested (help) edit
^ Chou, Y. C.; Liao, J. F.; Chang, W. Y.; Lin, M. F.; Chen, C. F. (1999). "Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan". Brain Research 821 (2): 516–519. doi:10.1016/S0006-8993(99)01125-7. PMID 10064839. edit

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