Dimemorfan

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Dimemorfan
Dimemorfan.svg
Systematic (IUPAC) name
(4bS,8aS,9S)-3,11-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
?
Identifiers
CAS number 36309-01-0 YesY
ATC code R05DA11
PubChem CID 3037918
ChemSpider 16735785 YesY
UNII 623OAC38YU YesY
KEGG D07848 YesY
ChEMBL CHEMBL2106325
Chemical data
Formula C18H25N 
Mol. mass 255.398 g/mol
 YesY (what is this?)  (verify)

Dimemorfan is an antitussive or cough suppressant which acts as a sigma receptor agonist.[1][2] It is an analogue of dextromethorphan and dextrorphan, but lacks significant NMDA receptor antagonistic action and dissociative effects, thereby having reduced abuse potential and adverse effects in comparison.[3]

See also[edit]

References[edit]

  1. ^ Wang, H. H.; Chien, J. W.; Chou, Y. C.; Liao, J. F.; Chen, C. F. (2003). "Anti-amnesic effect of dimemorfan in mice". British Journal of Pharmacology 138 (5): 941–949. doi:10.1038/sj.bjp.0705117. PMC 1573728. PMID 12642396.  edit
  2. ^ Shin, E. J.; Nah, S. Y.; Kim, W. K.; Ko, K. H.; Jhoo, W. K.; Lim, Y. K.; Cha, J. Y.; Chen, C. F.; Kim, H. C. (2005). "The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via σ1 receptor activation: Comparison with the effects of dextromethorphan". British Journal of Pharmacology 144 (7): 908–918. doi:10.1038/sj.bjp.0705998. PMC 1576070. PMID 15723099.  edit
  3. ^ Chou, Y. C.; Liao, J. F.; Chang, W. Y.; Lin, M. F.; Chen, C. F. (1999). "Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan". Brain Research 821 (2): 516–519. doi:10.1016/S0006-8993(99)01125-7. PMID 10064839.  edit