Dimethylallyl pyrophosphate

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Dimethylallyl pyrophosphate
Skeletal formula
Ball-and-stick model
Names
IUPAC name
(hydroxy-(3-methylbut-2-enoxy) phosphoryl) oxyphosphonic acid
Other names
Dimethylallyl diphosphate; isoprenyl pyrophosphate; isoprenyl diphosphate
Identifiers
358-72-5 YesY
ChemSpider 19951350 YesY
Jmol-3D images Image
Image
MeSH 3,3-dimethylallyl+pyrophosphate
PubChem 647
Properties
C5H12O7P2
Molar mass 246.092
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY verify (what isYesY/N?)
Infobox references

Dimethylallyl pyrophosphate (or incorrectly, -diphosphate) (DMAPP) is an intermediate product of both mevalonic acid (MVA) pathway and DOXP/MEP pathway. It is an isomer of isopentenyl pyrophosphate (IPP) and exists in virtually all life forms. The enzyme isopentenyl pyrophosphate isomerase catalyzes the isomerization of DMAPP from IPP.

Precursor of DMAPP in the MVA pathway is mevalonic acid, and 2-C-methyl-D-erythritol-e-P in the MEP/DOXP pathway.

At present, it is believed that there is crossover between the two pathways in organisms that use both pathways to create terpenes and terpenoids, such as in plants, and that DMAPP is the crossover product.

Simplified version of the steroid synthesis pathway with the intermediates isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), geranyl pyrophosphate (GPP) and squalene shown. Some intermediates are omitted.

External links[edit]