Dimethylamine-corrinoid protein Co-methyltransferase

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Dimethylamine-corrinoid protein Co-methyltransferase
Identifiers
EC number 2.1.1.249
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Dimethylamine-corrinoid protein Co-methyltransferase (EC 2.1.1.249, mtbB (gene), dimethylamine methyltransferase) is an enzyme with system name dimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

dimethylamine + [Co(I) dimethylamine-specific corrinoid protein] \rightleftharpoons [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine

This enzyme is involved in methanogenesis from dimethylamine.

References[edit]

  1. ^ Wassenaar, R.W., Keltjens, J.T., van der Drift, C. and Vogels, G.D. (1998). "Purification and characterization of dimethylamine:5-hydroxybenzimidazolyl-cobamide methyltransferase from Methanosarcina barkeri Fusaro". Eur. J. Biochem. 253: 692–697. doi:10.1046/j.1432-1327.1998.2530692.x. PMID 9654067. 
  2. ^ Ferguson, D.J., Jr., Gorlatova, N., Grahame, D.A. and Krzycki, J.A. (2000). "Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". J. Biol. Chem. 275: 29053–29060. doi:10.1074/jbc.m910218199. PMID 10852929. 
  3. ^ Krzycki, J.A. (2004). "Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases". Curr. Opin. Chem. Biol. 8: 484–491. doi:10.1016/j.cbpa.2004.08.012. PMID 15450490. 

External links[edit]