From Wikipedia, the free encyclopedia
Jump to: navigation, search
Dimethylthiambutene structure.svg
Systematic (IUPAC) name
Clinical data
524-84-5 YesY
PubChem CID 10668
DrugBank DB01444 YesY
ChemSpider 10218 YesY
UNII 915D88LM9O YesY
ChEBI CHEBI:59781 YesY
Chemical data
Formula C14H17NS2
263.424 g/mol
Physical data
Melting point 169 to 170 °C (336 to 338 °F)
 YesY (what is this?)  (verify)

Dimethylthiambutene (N,N-Dimethyl-1-methyl-3,3-di-2-thienylallylamine, DMTB, trade names Ohton, Aminobutene, Dimethibutin, Kobaton, Takaton, Dimethibutin) is an opioid analgesic drug, most often used in veterinary medicine in Japan and to a lesser extent in other countries in the region and around the world. It is the most prominent and widely used of the thiambutenes, a series of open-chain opioids structurally related to methadone which are also called the thienyl derivative opioids which also includes diethylthiambutene and ethylmethylthiambutene, as well as the non-opioid cough suppressant tipepidine.

Dimethylthiambutene was developed in the United Kingdom in the late 1940s[1] and introduced to the market by Burroughs-Wellcome in 1951. Dimethylthiambutene is now under international control under the UN Single Convention on Narcotic Drugs 1961, the laws governing habit-forming substances in virtually all countries and Schedule I of the US Controlled Substances Act of 1970 due to high abuse potential and never being introduced clinically in the United States; other countries regulate it much as morphine or diamorphine. Its DEA ACSCN is 9619 and it had a zero manufacturing quota in 2013.

See also[edit]


  1. ^ U.S. Patent 2,561,899 - Dithienyl Allyl Amines