Molecular formula C
40H 80NO 8P
Molar mass 734.039 g/mol
Except where noted otherwise, data are given for materials in their
standard state (at 25 °C (77 °F), 100 kPa)
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Dipalmitoylphosphatidylcholine ( DPPtdCho) is a phospholipid (and a lecithin) consisting of two palmitic acids and is the major constituent of pulmonary surfactant. It is also the only surface active component of lung surfactant capable of lowering surface tension to near zero levels. DPPtdCho is synthesized mainly through remodeling of phosphatidylcholine.
It is thought that a lysophosphatidylcholine (lysoPC) acyltransferase may play a critical role in its synthesis. The identity of this acyltransferase has not yet been confirmed.
Dipalmitoylphosphatidylcholine is an exception to the [1 ] rule of thumb that biological phospholipids are synthesized with a saturated fat at the R1 position and an unsaturated fat at the R2 position.
It is also used for research purposes in studying
liposomes, lipid bilayers, and model biological membranes and in the formation of reconstituted HDL (rHDL) particles.
See also [ edit ]
Molecular Dynamics simulation of DPPC lipid bilayer formation in two phase systems
References [ edit ]
DPPC molecule is zwitteronic having a negative charge on the phosphate group and a positive charge on the amine