Diphenadione

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Diphenadione
Structural formula of diphenadione
Ball-and-stick model of the diphenadione molecule
Names
IUPAC name
2-(Diphenylacetyl)-1H-indene-1,3(2H)-dione
Other names
Diphacinone; Diphenandione
Identifiers
ATC code B01AA10
82-66-6 YesY
ChEMBL ChEMBL1413199
ChemSpider 6463
Jmol-3D images Image
KEGG D07136 YesY
PubChem 6719
UNII 54CA01C6JX YesY
Properties
C23H16O3
Molar mass 340.37 g·mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY verify (what isYesY/N?)
Infobox references

Diphenadione is a vitamin K antagonist which has anticoagulant effects and is used as a rodenticide against rats, mice, voles, ground squirrels and other rodents. This chemical compound is an anti-coagulant with longer activity than warfarin and other synthetic indandione anticoagulants.[1]

Safety and toxicity[edit]

Diphenadione is highly toxic for human skin by all means of contact. Consumption of the drug may cause major blood clotting abnormalities and irregular heartbeats.[2] An online pesticide database gives more information about the safety of diphenadione.[3] The U.S. Environmental Protection Agency has issued a safety handbook which explains how incidents of poisoning with similar rodenticides are usually treated.[4] For treatment purposes Vitamin K antagonists like diphenadione are placed under the heading of coumarins and indandiones. The handbook notes that "...as agents specifically designed to kill mammals, often their toxicity is very similar for the target rodents and for humans."[5]

References[edit]

  1. ^ "Diphacinone". Pmep.cce.cornell.edu. Retrieved 2011-12-07. 
  2. ^ Bell Laboratories, Inc. July, 1990. Diphacinone Technical: MSDS. Bell Labs, Madison, WI.
  3. ^ "Diphacinone - toxicity, ecological toxicity and regulatory information". Pesticideinfo.org. Retrieved 2011-12-07. 
  4. ^ Routt Reigart and James Roberts (1999). Recognition and management of pesticide poisonings (5th edition). USEPA. 
  5. ^ Reigart, page 169.