Dirlotapide
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| Systematic (IUPAC) name | |
| 1-Methyl-N-[(1S)-2-(methyl-(phenylmethyl)amino)-2-oxo-1-phenylethyl]-5-[ [oxo-[2-[4-(trifluoromethyl)phenyl]phenyl]methyl]amino]-2-indolecarboxamide | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 481658-94-0 |
| ATCvet code | QA08AB91 |
| PubChem | CID 9917862 |
| ChemSpider | 8093509  |
| UNII | 578H0RMP25 |
| KEGG | D03867 |
| ChEMBL | CHEMBL410414 |
| Chemical data | |
| Formula | C40H33F3N4O3 |
| Mol. mass | 674.71 g/mol |
| SMILES | eMolecules & PubChem |
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Dirlotapide is a drug used to treat obesity in dogs. It is manufactured by Pfizer and marketed as Slentrol.
It works as a selective microsomal triglyceride transfer protein inhibitor. This blocks the assembly and release of lipoproteins into the bloodstream, thereby reducing fat absorption. It also elicits a satiety signal from lipid-filled cells lining the intestine.
It is supplied as an oral solution. It is not intended for use in humans, cats, or parrots.
On January 5 2007, the U.S. Food and Drug Administration (FDA) approved Slentrol, the first time the FDA has approved a drug for obese dogs.[1]
[edit] References
- ^ "FDA approves 1st drug for obese dogs". Yahoo. Archived from the original on January 8, 2007. http://web.archive.org/web/20070108052816/http://news.yahoo.com/s/ap/20070106/ap_on_he_me/doggie_diet_drug. Retrieved 2007-01-06.
[edit] External links
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