Disaccharidases are glycoside hydrolases, enzymes that break down certain types of sugars called disaccharides into simpler sugars called monosaccharides. A genetic defect in one of these enzymes will cause a disaccharide intolerance, such as lactose intolerance or sucrose intolerance.
Examples of disaccharidases
- Lactase (breaks down lactose into glucose and galactose)
- Maltase (breaks down maltose into 2 glucoses)
- Sucrase (breaks down sucrose into glucose and fructose)
- Trehalase (breaks down trehalose into 3 glucoses)
- Charles Scriver, Beaudet, A.L., Valle, D., Sly, W.S., Vogelstein, B., Childs, B., Kinzler, K.W. (Accessed 2007). The Online Metabolic and Molecular Bases of Inherited Disease. New York: McGraw-Hill. - Summaries of 255 chapters, full text through many universities. There is also the OMMBID blog.
- Further reading
- Poley, J. R.; Bhatia, M.; Welsh, J. D. (1978). "Disaccharidase deficiency in infants with cow's milk protein intolerance. Response to treatment". Digestion 17 (2): 97–107. doi:10.1159/000198100. PMID 627328.
- Neale, G (1971). "Disaccharidase deficiencies". J Clin Pathol Suppl (R Coll Pathol) 5: 22–28. PMC 1176256.
- Laws, J. W.; Neale, G. (1966). "Radiological diagnosis of disaccharidase deficiency". Lancet 2 (7455): 139–143. doi:10.1016/S0140-6736(66)92424-X. PMID 4161630.
- Laws, J. W.; Spencer, J.; Neale, G. (1967). "Radiology in the diagnosis of disaccharidase deficiency". The British journal of radiology 40 (476): 594–603. doi:10.1259/0007-1285-40-476-594. PMID 4952296.
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