Disease theory of alcoholism

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Alcohol Dependence
Classification and external resources
ICD-10 F10.2
ICD-9 303
A 1904 advertisement labeling alcoholism a "disease".

The modern disease theory of alcoholism states that problem drinking is sometimes caused by a disease of the brain, characterized by altered brain structure and function. The American Medical Association (AMA) had declared that alcoholism was an illness in 1956. In 1991, The AMA further endorsed the dual classification of alcoholism by the International Classification of Diseases under both psychiatric and medical sections.

Theory[edit]

Alcoholism is a chronic problem. However, if managed properly, damage to the brain can be stopped and to some extent reversed.[1]  In addition to problem drinking, the disease is characterized by symptoms including an impaired control over alcohol, compulsive thoughts about alcohol, and distorted thinking.[2] Alcoholism can also lead indirectly, through excess consumption, to physical dependence on alcohol, and diseases such as cirrhosis of the liver.

The risk of developing alcoholism depends on many factors, such as environment. Those with a family history of alcoholism are more likely to develop it themselves (Enoch & Goldman, 2001); however, many individuals have developed alcoholism without a family history of the disease.[citation needed] Since the consumption of alcohol is necessary to develop alcoholism, the availability of and attitudes towards alcohol in an individual's environment affect their likelihood of developing the disease. Current evidence indicates that in both men and women, alcoholism is 50–60% genetically determined, leaving 40-50% for environmental influences.[3]

In a review in 2001, McLellan et al. compared the diagnoses, heritability, etiology (genetic and environmental factors), pathophysiology, and response to treatments (adherence and relapse) of drug dependence vs type 2 diabetes mellitus, hypertension, and asthma. They found that genetic heritability, personal choice, and environmental factors are comparably involved in the etiology and course of all of these disorders, providing evidence that drug (including alcohol) dependence is a chronic medical illness.[4]

Genetics and Environment[edit]

According to the theory, genes play a strong role in the development of alcoholism.

Twin studies, adoption studies, and artificial selection studies have shown that a person's genes can predispose them to developing alcoholism. Evidence from twin studies show that concordance rates for alcoholism are higher for monozygotic twins than dizygotic twins—76% for monozygotic twins and 61% for dizygotic twins.[5] However, female twin studies demonstrate that females have much lower concordance rates than males.[5] Reasons for gender differences may be due to environmental factors, such as negative public attitudes towards female drinkers.[6] Twin studies suggest that males are more likely to have a genetic predisposition for alcoholism. However, this does not suggest that a male who does have a genetic predisposition will become an alcoholic. Sometimes the individual may never encounter an environmental trigger that leads to alcoholism.[citation needed]

Adoption studies also suggest a strong genetic tendency towards alcoholism. Studies on children separated from their biological parents demonstrates that sons of alcoholic biological fathers were more likely to become alcoholic, even though they have been separated and raised by non alcoholic parents.[5] Female show similar results, but to a lesser degree.[citation needed]

In artificial selection studies, specific strains of rats were bred to prefer alcohol. These rats preferred drinking alcohol over other liquids, resulting in a tolerance for alcohol and exhibited a physical dependency on alcohol.[5] Rats that were not bred for this preference did not have these traits (Lumeng, Murphy, McBride, & Li, 1995).[5] Upon analyzing the brains of these two strains of rats, it was discovered that there were differences in chemical composition of certain areas of the brain. This study suggests that certain brain mechanisms are more genetically prone to alcoholism.[citation needed]

The convergent evidence from these studies present a strong case for the genetic basis of alcoholism.[citation needed]

History[edit]

Historians debate who has primacy in arguing that habitual drinking carried the characteristics of a disease. Some note that Scottish physician Thomas Trotter was the first to characterize excessive drinking as a disease, or medical condition.[7]

Others point to American physician Benjamin Rush (1745–1813), a signatory to the United States Declaration of Independence — who understood drunkenness to be what we would now call a "loss of control" — as possibly the first to use the term "addiction" in this sort of meaning.[8]

My observations authorize me to say, that persons who have been addicted to them, should abstain from them suddenly and entirely. 'Taste not, handle not, touch not' should be inscribed upon every vessel that contains spirits in the house of a man, who wishes to be cured of habits of intemperance.

—Levine, H.G., The Discovery of Addiction: Changing Conceptions of Habitual Drunkenness in America [8]

Rush argued that "habitual drunkenness should be regarded not as a bad habit but as a disease", describing it as "a palsy of the will".[9] His views are described by Valverde[10] and by Levine:[8]

Then there is Swedish physician Magus Huss who coined the term "alcoholism" in his book Alcoholismus chronicus.[11] Some argue that he was the first to systematically describe the physical characteristics of habitual drinking and claim that it was a disease. However, this came decades after Rush and Trotter wrote their works, and some historians argue that the idea that habitual drinking was a diseased state emerged earlier.[12]

Given all this controversy, the best one can say is that the idea that habitual alcohol drinking was a disease had become more acceptable by the middle of the nineteenth century, although many writers still argued it was a vice, a sin, and not the purview of medicine but of religion.[13]

Between 1980 and 1991, medical organizations, including the AMA, worked together to establish policies regarding their positions on the disease theory. These policies were developed in 1987 in part because third-party reimbursement for treatment was difficult or impossible unless alcoholism were categorized as a disease. The policies of the AMA, formed through consensus of the federation of state and specialty medical societies within their House of Delegates, state, in part:

"The AMA endorses the proposition that drug dependencies, including alcoholism, are diseases and that their treatment is a legitimate part of medical practice."

In 1991, the AMA further endorsed the dual classification of alcoholism by the International Classification of Diseases under both psychiatric and medical sections.

Controlled drinking[edit]

The disease theory is often interpreted as implying that problem drinkers are incapable of returning to controlled drinking, and therefore that treatment should focus on total abstinence. Some critics have used evidence of problem drinkers' returning to controlled drinking to dispute the disease theory.

The first major empirical challenge to this interpretation of the disease theory followed a 1962 study by Dr. D. L. Davies.[14] Davies' follow-up of 93 problem drinkers found that 7 of them were able to return to "controlled drinking" (less than 7 drinks per day for at least 7 years). Davies concluded that "the accepted view that no alcohol addict can ever again drink normally should be modified, although all patients should be advised to aim at total abstinence"; After the Davies study, several other researchers reported cases of problem drinkers returning to controlled drinking.[15][16][17][18][19][20][21][22]

In 1976, a major study commonly referred to as the RAND report, published evidence of problem drinkers learning to consume alcohol in moderation.[23] The publication of the study renewed controversy over how people suffering a disease which reputedly leads to uncontrollable drinking could manage to drink controllably. Subsequent studies also reported evidence of return to controlled drinking.[24] Similarly, according to a 2002 National Institute on Alcohol Abuse and Alcoholism (NIAAA) study, about one of every six (17.7%) of alcohol dependent adults in the U.S. whose dependence began over one year previously had become "low-risk drinkers" (less than 14 drinks per week and 5 drinks per day for men, or less than 7 per week and 4 per day for women). This modern longitudinal study surveyed more than 43,000 individuals representative of the U.S. adult population, rather than focusing solely on those seeking or receiving treatment for alcohol dependence. "Twenty years after onset of alcohol dependence, about three-fourths of individuals are in full recovery; more than half of those who have fully recovered drink at low-risk levels without symptoms of alcohol dependence." [25]

However, many researchers have debated the results of the smaller studies. A 1994 followup of the original 7 cases studied by Davies suggested that he "had been substantially misled, and the paradox exists that a widely influential paper which did much to stimulate new thinking was based on faulty data."[26] The most recent study, a long-term (60 year) follow-up of two groups of alcoholic men by George Vaillant at Harvard Medical School concluded that "return to controlled drinking rarely persisted for much more than a decade without relapse or evolution into abstinence."[27] Vaillant also noted that "return-to-controlled drinking, as reported in short-term studies, is often a mirage."

The second RAND study, in 1980, found that alcohol dependence represents a factor of central importance in the process of relapse. Among people with low dependence levels at admission, the risk of relapse appears relatively low for those who later drank without problems. But the greater the initial level of dependence, the higher the likelihood of relapse for nonproblem drinkers. (Table 7.8 pg. 152) The second RAND study findings have been strengthened by subsequent research by Dawson et al 2005 which found that severity was associated positively with the likelihood of abstinent recovery and associated negatively with the likelihood of non-abstinent recovery or controlled drinking.

Legal considerations[edit]

In 1988, the US Supreme Court upheld a regulation whereby the Veterans' Administration was able to avoid paying benefits by presuming that primary alcoholism is always the result of the veteran's "own willful misconduct." The majority opinion written by Justice Byron R. White echoed the District of Columbia Circuit's finding that there exists "a substantial body of medical literature that even contests the proposition that alcoholism is a disease, much less that it is a disease for which the victim bears no responsibility".[28] He also wrote: "Indeed, even among many who consider alcoholism a "disease" to which its victims are genetically predisposed, the consumption of alcohol is not regarded as wholly involuntary." However, the majority opinion stated in conclusion that "this litigation does not require the Court to decide whether alcoholism is a disease whose course its victims cannot control. It is not our role to resolve this medical issue on which the authorities remain sharply divided." The dissenting opinion noted that "despite much comment in the popular press, these cases are not concerned with whether alcoholism, simplistically, is or is not a "disease.""[29]

The American Bar Association "affirms the principle that dependence on alcohol or other drugs is a disease."[30]

Current acceptance[edit]

The current mainstream scientific and medical view is that alcoholism is a disease, although some debate on this topic still occurs.[31][32]

In 2004, the World Health Organisation published a detailed report on alcohol and other psychoactive substances entitled "Neuroscience of psychoactive substance use and dependence".[33] It stated that this was the "first attempt by WHO to provide a comprehensive overview of the biological factors related to substance use and dependence by summarizing the vast amount of knowledge gained in the last 20-30 years. The report highlights the current state of knowledge of the mechanisms of action of different types of psychoactive substances, and explains how the use of these substances can lead to the development of dependence syndrome." The report states that "dependence has not previously been recognized as a disorder of the brain, in the same way that psychiatric and mental illnesses were not previously viewed as being a result of a disorder of the brain. However, with recent advances in neuroscience, it is clear that dependence is as much a disorder of the brain as any other neurological or psychiatric illness."

The American Society of Addiction Medicine and the American Medical Association both maintain extensive policy regarding alcoholism. The American Psychiatric Association recognizes the existence of "alcoholism" as the equivalent of alcohol dependence. The American Hospital Association, the American Public Health Association, the National Association of Social Workers, and the American College of Physicians classify "alcoholism" as a disease.

In the US, the National Institutes of Health has a specific institute, the National Institute on Alcohol Abuse and Alcoholism (NIAAA), concerned with the support and conduct of biomedical and behavioral research on the causes, consequences, treatment, and prevention of alcoholism and alcohol-related problems. It funds approximately 90 percent of all such research in the United States. The official NIAAA position is that "alcoholism is a disease. The craving that an alcoholic feels for alcohol can be as strong as the need for food or water. An alcoholic will continue to drink despite serious family, health, or legal problems. Like many other diseases, alcoholism is chronic, meaning that it lasts a person's lifetime; it usually follows a predictable course; and it has symptoms. The risk for developing alcoholism is influenced both by a person's genes and by his or her lifestyle."[34]

Criticism[edit]

Some physicians, scientists and others have rejected the disease theory of alcoholism on logical, empirical and other grounds.[35][36][37][38][39][40]

Some critics of the disease model argue alcoholism is a choice, not a disease, and stripping alcohol abusers of their choice, by applying the disease concept, is a threat to the health of the individual; the disease concept gives the substance abuser an excuse. A disease cannot be cured by force of will; therefore, adding the medical label transfers the responsibility from the abuser to caregivers. Inevitably the abusers become unwilling victims, and just as inevitably they take on that role. They argue that the disease theory of alcoholism exists only to benefit the professionals' and governmental agencies responsible for providing recovery services, and the disease model has not offered a solution for those attempting to stop abusive alcohol and drug use.[41]

These critics hold that by removing some of the stigma and personal responsibility the disease concept actually increases alcoholism and drug abuse and thus the need for treatment.[41] This is somewhat supported by a study which found that a greater belief in the disease theory of alcoholism and higher commitment to total abstinence to be factors correlated with increased likelihood that an alcoholic would have a full-blown relapse (substantial continued use) following an initial lapse (single use).[42] However, the authors noted that "the direction of causality cannot be determined from these data. It is possible that belief in alcoholism as a loss-of-control disease predisposes clients to relapse, or that repeated relapses reinforce clients' beliefs in the disease model."

A national study of doctors in the United States reported in The Road to Recovery asked them what proportion of alcoholism is a disease and what proportion is a personal weakness. The average proportion thought to be personal weakness was 31 percent. Significantly, only 12 percent of doctors considered alcoholism to be 100 percent a disease.

Another study found that only 25 percent of physicians believed that alcoholism is a disease. The majority believed alcoholism to be a social or psychological problem instead of a disease. (S.I. Mignon. Physicians' Perceptions of Alcoholics: The Disease Concept Reconsidered. Alcoholism Treatment Quarterly, 1996, v. 14, no. 4, pp. 33–45)

A survey of physicians at an annual conference of the International Doctors in Alcoholics Anonymous reported that 80 percent believe that alcoholism is merely bad behavior instead of a disease. (Barrier to Treatment. Alcoholmd - Information About Alcohol and Medicine)

Dr. Thomas R. Hobbs says that "Based on my experiences working in the addiction field for the past 10 years, I believe many, if not most, health care professionals still view alcohol addiction as a willpower or conduct problem and are resistant to look at it as a disease." (T.R. Hobbs. Managing Alcoholism as a Disease. Physician's News Digest, 1998.)

Alcoholics-Anonymous says that "Some professionals will tell you that alcoholism is a disease while others contend that it is a choice" and "some doctors will tell you that it is in fact a disease." (Alcoholics-Anonymous. What Is Alcoholism? www.alcoholics-anonymous.com/what-is-alcoholism.htm)[43]

Dr. Lynn Appleton says that "Despite all public pronouncements about alcoholism as a disease, medical practice rejects treating it as such. Not only does alcoholism not follow the model of a 'disease,' it is not amenable to standard medical treatment." She says that "Medical doctors' rejection of the disease theory of alcoholism has a strong basis in the biomedical model underpinning most of their training" and that "medical research on alcoholism does not support the disease model." (Lynn M. Appleton. Rethinking medicalization. Alcoholism and anomalies. Chapter in editor Joel Best's Images of Issues. Typifying Contemporary Social Problems. NY: Aldine De Gruyter, 1995, page 65 and page 69. 2nd edition

"Many doctors have been loath to prescribe drugs to treat alcoholism, sometimes because of the belief that alcoholism is a moral disorder rather than a disease," according to Dr. Bankole Johnson, Chairman of the Department of Psychiatry at the University of Virginia.[44] Dr Johnson's own pioneering work has made important contributions to the understanding of alcoholism as a disease.[45]

Certain medications including opioid antagonists such as naltrexone have been shown to be effective in the treatment of alcoholism, although research has not yet demonstrated long-term efficacy.[46]

Frequency and quantity of alcohol use are not related to the presence of the condition that is, people can drink a great deal without necessarily being alcoholic and alcoholics may drink minimally or infrequently.[2][47]

See also[edit]

References[edit]

  1. ^ Andreas J. Bartsch, György Homola, Armin Biller, Stephen M. Smith, Heinz-Gerd Weijers, Gerhard A. Wiesbeck, Mark Jenkinson, Nicola De Stefano, László Solymosi, and Martin Bendszus (2007). "Manifestations of early brain recovery associated with abstinence from alcoholism". Brain 130 (1). Oxford University Press. pp. 36–47. doi:10.1093/brain/awl303. Retrieved 7 Aug 2013. 
  2. ^ a b Morse, RM; Flavin, DK (August 26, 1992). "The definition of alcoholism, The Joint Committee of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism". The Journal of the American Medical Association 268 (8): 1012–4. doi:10.1001/jama.1992.03490080086030. PMID 1501306. 
  3. ^ Dick, DM; Bierut, LJ (2006). "The Genetics of Alcohol Dependency". Current Psychiatric Reports 8 (2): 151–7. doi:10.1007/s11920-006-0015-1. PMID 16539893. 
  4. ^ McLellan, AT; Lewis, DC; O'Brien, CP; Kleber, HD (2000). "Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation". JAMA: the Journal of the American Medical Association 284 (13): 1689–95. doi:10.1001/jama.284.13.1689. PMID 11015800. 
  5. ^ a b c d e Carlson [et al.], Neil R. (2005). Psychology: The Science of Behaviour 3rd Canadian Edition. Pearson. pp. 75–76. ISBN 0-205-45769-X. 
  6. ^ "Differences in drinking among male and female students: Dr. Engs". Indiana.edu. Retrieved 2012-05-30. 
  7. ^ Trotter, T. (Porter, R., ed.), An Essay, Medical, Philosophical, and Chemical, on Drunkenness and Its Effects on the Human Body, Routledge, (London), 1988. (This a facsimile of the first (1804) London edition. The book itself was based on the thesis "De ebrietate, ejusque effectibus in corpus humanum" that Trotter had presented to Edinburgh University in 1788.)
  8. ^ a b c Levine, H.G., "The Discovery of Addiction: Changing Conceptions of Habitual Drunkenness in America", Journal of Studies on Alcohol, Vol.39, No.1, (January 1978), pp.143-174. (Reprint: Journal of Substance Abuse Treatment, Vol.2, No.1, (1985), pp.43-57.) Available at [1][dead link]
  9. ^ Valverde (1998, p.2). Rush expounded his views in a book published in 1808.<re>Rush, B., An Inquiry into the Effects of Ardent Spirits upon the Human Body and Mind: With an Account of the Means of Preventing, and of the Remedies for Curing Them, Thomas Dobson, (Philadelphia), 1808.
  10. ^ Valverde, M., Diseases of the Will: Alcohol and the Dilemmas of Freedom, Cambridge University Press, (Cambridge), 1998.
  11. ^ Hasso Spode has championed Huss's work to be seen as having primacy. See the good discussion in the ADHS Forum in the Social History of Alcohol and Drugs: An Interdisciplinary Journal 20 (2005): 105-40 where several noted addiction historians discuss the changing attitudes of alcohol, tobacco and other drugs and the origins of their ideas
  12. ^ Along with Levine, see Roy Porter ("Drinking Man's Disease: the 'Pre-History' of Alcoholism in Georgian Britain," British Journal of Addiction 80 (1985): 385-96) who places the idea to emerge with Trotter, Jessica Warner ["'Resolved to Drink No More':Addiction as a preindustrial construct" Journal of Studies on Alcohol 55 (1994): 685-91] who uses a narrow reading of seventeenth century sermons to place it in the 1600s, Peter Ferentzy ["From Sin to Disease: Differences and similarities between past and current conceptions on 'chronic drunkenness'" Contemporary Drug Problems 28 (2001): 362-90]who successfully challenges Warner's argument by showing that the term "disease" was applied to many conditions that had little to do with physical debility, and James Nicholls ["Vinum Britannicum: The 'Drink Question' in Early Modern England" Social History of Alcohol and Drugs: An interdisciplinary Journal 22 (2008): 6-25] who pulls it all together and argues that the idea emerged at different times in different places.
  13. ^ See, for example, books with such telling titles as John Edwards Todd, Drunkenness, a Vice--not a Disease (1882).
  14. ^ Davies, D.L. (1962). "Normal drinking in recovered alcohol addicts". Quarterly Journal of Studies on Alcohol 23: 94–104. PMID 13883819. 
  15. ^ Caddy, G. R.; Lovibond, S. H. (1976). "Self-regulation and discriminated aversive conditioning in the modification of alcoholics' drinking behavior". Behavior Therapy 7 (2): 223–230. doi:10.1016/S0005-7894(76)80279-1. 
  16. ^ Goodwin, D. W., Crane, J. B., & Guze, S. B. (1971). Felons who drink: An 8-year follow-up. Quarterly Journal of Studies on Alcohol, 32, 136-147
  17. ^ Miller, W. R.; Caddy, G. R. (1977). "Abstinence and controlled drinking in the treatment of problem drinkers". Journal of Studies on Alcohol 38 (5): 986–1003. PMID 329004. 
  18. ^ Pattison, E. M.; Sobell, M. B.; Sobell, L. C. (1977). "Emerging concepts of alcohol dependence. New York: Springer; Schaefer, H. H. (1971). A cultural delusion of alcoholics". Psychological Reports 29 (2): 587–589. PMID 5126763. 
  19. ^ Schuckit, M. A.; Winokur, G. A. (1972). "A short-term followup of women alcoholics". Diseases of the Nervous System 33 (10): 672–678. PMID 4648267. 
  20. ^ Sobell, M. B.; Sobell, L. C. (1973). "Alcoholics treated by individualized behavior therapy: One year treatment outcomes". Behaviour Research and Therapy 11 (4): 599–618. doi:10.1016/0005-7967(73)90118-6. PMID 4777652. 
  21. ^ Sobell, M. B.; Sobell, L. C. (1976). "Second year treatment outcome of alcoholics treated by individualized behavior therapy: Results". Behaviour Research and Therapy 14 (3): 195–215. doi:10.1016/0005-7967(76)90013-9. PMID 962778. 
  22. ^ Vogler, R. E.; Compton, J. V.; Weissbach, J. A. (1975). "Integrated behavior change techniques for alcoholism". Journal of Consulting and Clinical Psychology 43 (2): 233–243. doi:10.1037/h0076533. PMID 1120834. 
  23. ^ Armor, D. J., Polich, J. M., & Stambul, H. B. (1976). Alcoholism and treatment. Rand Corporation
  24. ^ Polich, J. M.; Armor, D. J.; Braiker, H. B. (1981). "The course of alcoholism: Four years after treatment. New York: Wiley; Heather, N., & Robertson, I. (1981). Controlled drinking. London: Methuen; Robertson, I. H., & Heather, N. (1982). A survey of controlled drinking treatment in Britain. British Journal on Alcohol and Alcoholism, 17, 102- 105; J.H. Mendelson and N.K. Mello (Eds.), The Diagnosis and Treatment of Alcoholism (Second Edition), McGraw-Hill, New York, 1985; G. Nordström and M. Berglund (1987), A prospective study of successful long-term adjustment in alcohol dependence: Social drinking versus abstinence". Journal of Studies on Alcohol 48 (2): 95–103. PMID 3560955. 
  25. ^ NIH/National Institute on Alcohol Abuse and Alcoholism. 2001-2002 Survey Finds That Many Recover From Alcoholism: Researchers Identify Factors Associated with Abstinent and Non-Abstinent Recovery. National Institute on Alcohol Abuse and Alcoholism press release, January 19, 2005; Dawson, DA; Grant, BF; Stinson, FS; Chou, PS; Huang, B; Ruan, WJ. (2005). "Recovery from DSM-IV alcohol dependence: United States, 2001-2002". Addiction 100 (3): 281–92. doi:10.1111/j.1360-0443.2004.00964.x. PMID 15733237. 
  26. ^ Edwards, G (1994). "D.L. Davies and 'Normal drinking in recovered alcohol addicts': the genesis of a paper". Drug and alcohol dependence 35 (3): 249–59. doi:10.1016/0376-8716(94)90082-5. PMID 7956756. 
  27. ^ Vaillant GE (August 2003). "A 60-year follow-up of alcoholic men". Addiction 98 (8): 1043–51. doi:10.1046/j.1360-0443.2003.00422.x. PMID 12873238. 
  28. ^ TRAYNOR v. TURNAGE, 485 U.S. 535 (1988)
  29. ^ "Alcoholics lose some VA benefits - Veterans Administration". Science News. 1988. 
  30. ^ http://www.abanet.org/subabuse/07report_with_recommendation.pdf
  31. ^ http://www.bhrm.org/papers/Counselor3.pdf
  32. ^ Ruth Engs (ed.): Chpt.6 Controversies book-disease concept of alcoholism should be rejected
  33. ^ Pagetit
  34. ^ FAQs for the General Public
  35. ^ Heavy Drinking, Fingarette, Herbert, University of California Press, Berkeley and Los Angeles, California, 1998 ISBN 0-520-06754-1
  36. ^ Robin Room - Papers by Robin Room
  37. ^ Peele, S. (1989, 1995), Diseasing of America: How we allowed recovery zealots and the treatment industry to convince us we are out of control. Lexington, MA/San Francisco: Lexington Books/Jossey-Bass.
  38. ^ International Handbook of Alcohol Dependence and Problems, Nich Heataher, Editor, Timothy J. Peters, Editor, Tim Stockwell, Editor, Wiley, 2001, ISBN 978-0-471-98375-0
  39. ^ White, W. (2000). "The Rebirth of the Disease Concept of Alcoholism in the 20th Century". Counselor 1 (2): 62–66. 
  40. ^ Vaillant, George Eman (March 1990). "We should retain the disease concept of alcoholism". Harvard Medical School Mentul Health Letter 6: 4–6. 
  41. ^ a b "Alcoholism: A disease of speculation". Baldwinresearch.com. 2002-04-14. Retrieved 2012-05-30. 
  42. ^ Miller, William R; Westerberg, Verner S; Harris, Richard J; Tonigan, J Scott (1996). "What predicts relapse? Prospective testing of antecedent models". Addiction 91 (Supplement): S151–S171. doi:10.1046/j.1360-0443.91.12s1.7.x. PMID 8997790. 
  43. ^ "Alcholics Anonymous. What Is Alcoholism?". Retrieved 13 October 2013. 
  44. ^ Hathaway, William Headache pill eases alcohol cravings Hartford Courant, October 10, 2007
  45. ^ Hazelden - Bankole Johnson, Ph.D., 2001 winner
  46. ^ Opioid Antagonists for Alcohol Dependence, Srisurapanont M and Jarusuraisin N, Cochrane Database of Systematic Reviews (Online) 2005 Jan 25;(1):CD001867
  47. ^ Esser, M. B.; Hedden, S. L.; Kanny, D.; Brewer, R. D.; Gfroerer, J. C.; Naimi, T. S. (2014). "Prevalence of Alcohol Dependence Among US Adult Drinkers, 2009–2011". Preventing Chronic Disease 11. doi:10.5888/pcd11.140329.  edit