Chlorothiazide
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| Systematic (IUPAC) name |
| 6-chloro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide |
| Clinical data |
| Trade names |
Diuril |
| AHFS/Drugs.com |
monograph |
| MedlinePlus |
a682341 |
| Pregnancy cat. |
C(US) |
| Legal status |
℞-only (US) |
| Routes |
Oral |
| Pharmacokinetic data |
| Metabolism |
Nil |
| Half-life |
45 to 120 minutes |
| Excretion |
Renal |
| Identifiers |
| CAS number |
58-94-6 |
| ATC code |
C03AA04 |
| PubChem |
CID 2720 |
| DrugBank |
APRD00721 |
| ChemSpider |
2619  Y |
| UNII |
77W477J15H Y |
| KEGG |
D00519 Y |
| ChEBI |
CHEBI:3640 Y |
| ChEMBL |
CHEMBL842 Y |
| Chemical data |
| Formula |
C7H6ClN3O4S2 |
| Mol. mass |
295.72 g/mol |
| SMILES |
eMolecules & PubChem |
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InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13) Y
Key:JBMKAUGHUNFTOL-UHFFFAOYSA-N Y
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 Y(what is this?) (verify)
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Chlorothiazide sodium (Diuril) is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive.
Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism than furosemide, and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another without risk of toxicity. Because it is absorbed enterically there are no risks associated with chlorothiazide as there are with furosemide administration.
[edit] Indications
- Large amount of excess fluid including:
[edit] Contraindications
- 500 mg–1 g once or twice a day, by mouth or through NG tube (reconstituted suspension)
- May also be given intravenously, and should be given first if given in combination with IV lasix since it potentiate's the diuretic effect of furosemide.
[edit] Side effects
[edit] History
The Research team of Merck Sharp and Dohme Research Laboratories: Karl H. Beyer, Jr., M.D., Ph.D.; James M. Sprague, Ph.D.; John E. Baer, Ph.D.; and Frederick C. Novello, Ph.D. created a new series of medications, the thiazide diuretics, which includes chlorothiazide. They won an Albert Lasker Special Award in 1975 for its creation. http://www.laskerfoundation.org/awards/formaward.htm
[edit] Chemical
Novello, Frederick C.; Sprague, James M. (1957). Journal of the American Chemical Society 79 (8): 2028. doi:10.1021/ja01565a079.
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