The municipality covers seven barangays, originally part of Angat, Norzagaray, and San Miguel. These are Pulong Sampaloc and Camachile of Angat; Bayabas and Kabayunan of Norzagaray; Talbac, Camachin and Kalawakan of San Miguel.
Doña Remedios Trinidad is the largest municipality in Bulacan. It lies on the southern edge of the Sierra Madre mountain range, and partially embracing two major portions of the Angat Watershed reservation: the Bulacan forest reserve and the Biak-na-Bato National Park, comprising 327.3 km² of alienable and disposable public land.
Bulacan P11-billion bulk water supply project
On December 12, 2007, Bulacan and the Metropolitan Waterworks and Sewerage System (MWSS) signed an agreement for the development of an P11-billion bulk water supply project. Ayala-owned Manila Water Co. Inc. will implement the project. MWSS and Manila Water will provide a financial package of an infrastructure grant, a P10-million development assistance and a P10-million royalty fee to the towns of Norzagaray and Doña Remedios Trinidad, which will host the water supply project.