Dobrava-Belgrade virus

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Dobrava-Belgrade virus
Virus classification
Group: Group V ((-)ssRNA)
Order: Unassigned
Family: Bunyaviridae
Genus: Hantavirus
Species: Dobrava-Belgrade virus

Dobrava-Belgrade virus (DOBV), also known as Dobrava virus, is an enveloped, single-stranded, negative-sense RNA virus species of Old World Hantavirus. It is one of several species of Hantavirus that is the causative agent of severe Hantavirus hemorrhagic fever with renal syndrome. It was first isolated from yellow-necked mice (Apodemus flavicollis) found in Dobrava Village, Slovenia, Yugoslavia.[1] It was subsequently isolated in striped field mice in Estonia and other parts of Eastern Europe. It has also been found in Germany but the reservoir host there is unknown. [2]


Dobrava virus and the variants of Dobrava-Belgrade virus have been found in the Yellow-necked mouse (Apodemus flavicollis), the Striped field mouse (Apodemus agrarius) and Black Sea field mouse (Apodemus ponticus).

Morbidity and Mortality[edit]

The fatality rate is 12%, making Dobrava virus the most life-threatening hantavirus disease in Europe. Variant DOBV genotypes have different degrees of pathogenicity. [3]

See also[edit]


  1. ^ Avsic-Zupanc T, Xiao SY, Stojanovic R, Gligic A, van der Groen G, LeDuc JW.Characterization of Dobrava virus: a Hantavirus from Slovenia, Yugoslavia. J Med Virol. 1992 Oct;38(2):132-7.
  2. ^ Mathias Schlegel1, Boris Klempa1, Brita Auste, Margrit Bemmann, Jonas Schmidt-Chanasit, Thomas Büchner, Martin H. Groschup, Markus Meier, Anne Balkema-Buschmann, Hinrich Zoller, Detlev H. Krüger, and Rainer G. Ulrich. Dobrava-Belgrade Virus Spillover Infections, Germany. Dispatch. Volume 15, Number 12—December 2009.
  3. ^ Papa A.Dobrava-Belgrade virus: phylogeny, epidemiology, disease.Antiviral Res. 2012 Aug;95(2):104-17. doi: 10.1016/j.antiviral.2012.05.011. Epub 2012 May 30.

External links[edit]