Domenico Gargiulo (1609–1610 – ca. 1675) was an Italian painter of the Baroque period, mainly active in Naples and known for his landscapes.
He was also called Micco Spadaro because his father was a maker of swords (spade). He was trained in the workshop of the battle-painter Aniello Falcone, where he was contemporary of Andrea di Leone and Salvator Rosa. He also worked with Viviano Codazzi. His early works were influenced by Paul Bril and Filippo Napoletano. Among his pupils was Ignazio Oliva. He was patronized by a collectors such as Gaspar Roomer. He also worked in the Certosa di San Martino, where he painted in the Coro dei Conversi and Quarto del priori. He painted a representation of the insurrection by Masaniello and of the plague of 1656.