Drawn into Pool C with Puerto Rico, Spain, and Venezuela at Hiram Bithorn Stadium in San Juan, Puerto Rico once again, the Dominicans opened the round-robin round 1 with a decisive 9–3 victory over 2009 semifinalists Venezuela. A victory over Spain and a Puerto Rico win over Venezuela ensured advancement to the second round; the Dominicans clinched the top seed by defeating the hosts. In the second round, the Dominicans rallied past upstart Italy despite an early 4–0 deficit at Marlins Park in Miami, United States. Two ninth-inning runs pushed the Dominicans past the host Americans and into the semifinals. Another victory over Puerto Rico ensured the Dominicans of the top seed and a chance to avoid two-time defending champions Japan national baseball team. Instead, they would face the surprising semifinalists Netherlands. After an early 1–0 deficit, four 5th-inning runs pushed the Dominican Republic into the final, where a 3–0 victory gave them their first-ever World Baseball Classic title. New York Yankees second baseman Robinson Cano was named MVP of the tournament.
The Dominican Republic team participated in the 1992 Games, the first medal competition for the sport, and finished 6th. The team failed to qualify for another competition before baseball was eliminated from the Olympics after the 2008 Games.