"Don't Touch Me" was written by Jeannie Seely's husband, Hank Cochran, the songwriter who wrote Patsy Cline's "I Fall to Pieces" and Eddy Arnold's "Make the World Go Away". Country music singer, Buck Owens originally wanted to record the song, but before he could do so, Cochran gave the song to Seely instead. This was the first single recorded by Seely after recently signing with Monument records in early 1966. "Don't Touch Me" was recorded on March 12, 1966, in the Monument studios in Nashville. Later that same month the song was released to country radio stations and was became a major hit by late Spring. It remained for three weeks at No. 2 on the Billboard country singles charts, and even went as far as to become a minor pop hit, peaking at No. 85 on the Billboard pop singles chart. However, on the other two country charts (Cashbox and Record World), the song hit the No. 1 spot. Wilma Burgess's version was released almost simultaneously and reached No. 12 on the Billboard charts, receiving more sales on the strength of the Decca label.
At the time the song was released, few women recorded within the conservative confines of country music recorded material describing such explicit sexual desire as expressed in "Don't Touch Me". Following the song's success, other female Country singers to begin to release similarly "risky" songs (e.g. Loretta Lynn's "The Pill", Dottie West's "When It's Just You and Me", Dolly Parton's "Just Because I'm a Woman"). Seely later said in interviews that it was a song that women were thinking and wanted to hear. In 1967, Seely won the Grammy award for Best Female Country Vocal Performance for "Don't Touch Me", becoming only third woman to receive the award (Dottie West was the first to receive the award, when it was first introduced in 1965). "Don't Touch Me" set the stage for a string of Top 10 and Top 20 hits for Seely in the next couple of years.
According to numerous books, "Don't Touch Me" has been classified as a "classic" or "standard" in Country music to record. The song was placed at No. 97 in the book, Heartaches By the Number: Country Music's 500 Greatest Singles, when it was released in 2003.