|Born||26 February 1929|
|Died||15 December 2014
|Institutions||Walter and Eliza Hall Institute of Medical Research|
|Known for||discovering the colony stimulating factors|
Donald Metcalf AC FRS FAA (26 February 1929 – 15 December 2014) was an Australian medical researcher who spent most of his career at the Walter and Eliza Hall Institute of Medical Research in Melbourne. In 1954 he received the Carden Fellowship from the Anti-Cancer Council of Victoria; while he officially retired in 1996, he continued working and held his fellowship until his retirement in December 2014.
Metcalf studied medicine at the University of Sydney, and had his first experience of medical research in the laboratory of Professor Patrick de Burgh. In 1954 Metcalf was awarded up a Carden Fellowship from the Anti-Cancer Council of Victoria at the Walter and Eliza Hall Institute of Medical Research. There he initially studied virology and leukemia, later transitioning to hematology.
Metcalf's pioneering research revealed the control of blood cell formation and the role of hematopoietic cytokines. In the 1960s he developed techniques to culture blood cells, which led to the discovery of colony-stimulating factors (CSFs), including macrophage colony-stimulating factor, granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor. CSFs are cytokines that control white blood cell formation and are responsible for resistance to infection. CSFs are now widely used to boost the immune system for patients receiving chemotherapy, and to mobilise blood stem cells for transplants.
Metcalf has been awarded many international prizes including the 1986 Royal Society Wellcome Prize (now the GlaxoSmithKline Prize), the 1987 Bristol-Myers Award for Distinguished Achievement in Cancer Research (jointly with Leo Sachs), the 1998 Robert Koch Prize, the 1988 Armand Hammer Prize for Cancer Research, the 1989 General Motors Cancer Foundation Sloan Prize, the 1993 Lasker-DeBakey Clinical Medical Research Award, the 1993 Louisa Gross Horwitz Prize from Columbia University, the 1994 Jessie Stevenson Kovalenko Medal from the United States National Academy of Sciences, the 1994 Gairdner Foundation International Award, the 1995 Royal Society Royal Medal and, in 2007, a Lifetime Achievement Award from the American Association for Cancer Research.
- Hilton, Doug (2015). "Donald Metcalf (1929-2014) Discoverer of hormones that regulate blood-cell proliferation". Nature 517 (7536): 554. doi:10.1038/517554a. PMID 25631437.
- "Prof. Donald Metcalf Carden Fellow". The Cancer Council Victoria. 2014. Retrieved 15 December 2014.
- "Professor Don Metcalf". Australian Academy of Science.[dead link]
- Douglas Hilton, Warren Alexander and Nicos Nicola. "A tribute to Professor Donald Metcalf ", Walter and Eliza Hall Institute of Medical Research, 15 December 2014.
- It's an Honour: AO
- It's an Honour: AC
- It's an Honour: Centenary Medal
- Professor Don Metcalf lab page, the Walter and Eliza Hall Institute of Medical Research.
- Biography of Donald Metcalf,[dead link] on the website of Alphamed Press.
- Interview with Professor Donald Metcalf[dead link] conducted by Dr Max Blythe on 31 March 1998, in Video Histories of Australian Scientists, Australian Academy of Science, 2002
- Snapshots from history, the Cancer Council Victoria
- Emeritus Professor Donald Metcalf[dead link] : 2001 Prime Minister's Prize for Science
- Louisa Gross Horwitz Prize, cumc.columbia.edu
- A prof's own adventure, The Age, 25 November 2004