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Donnatal is a proprietary combination medication for the treatment of intestinal cramping due to various causes, often administered as part of a GI cocktail.[1] It is classed as an anticholinergic antispasmodic drug. Donnatal is marketed by PBM Pharmaceuticals. It is available as tablets, capsules, extended release tablets and elixir. Active ingredients are listed as: phenobarbital, hyoscyamine, atropine and scopolamine. The latter three ingredients being found in plants of the Solanaceae family.

Recent clinical trials showed that Donnatal was no more effective than plain antacid in relieving the symptoms of dyspepsia.[1][2] However, the active ingredients in Donnatal® have been shown to be more effective than placebo in treating moderately severe symptoms of irritable bowel syndrome.[3]

It is also a common component of a GI cocktail used in emergency rooms.


  1. ^ a b Berman DA, Porter RS, Graber M (2003). "The GI Cocktail is no more effective than plain liquid antacid: a randomized, double blind clinical trial". Journal of Emergency Medicine 25 (3): 239–244. doi:10.1016/S0736-4679(03)00196-3. PMID 14585449. 
  2. ^ Bowman J, Jones J (2006). "Use of lidocaine in the gastrointestinal cocktail for the treatment of dyspepsia". Emergency Medicine Journal 23 (11): 873–874. doi:10.1136/emj.2006.042168. PMC 2464394. PMID 17057145. 
  3. ^ Rhodes JB, Abrams JH, Manning RT (1978). "Controlled clinical trial of sedative-anticholinergic drugs in patients with the irritable bowel syndrome". Journal of Clinical Pharmacology 18 (7): 340–345. PMID 353089. 

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