Dorena is an unincorporated community in southeastern Mississippi County, Missouri, United States. It is located at the intersection of Route 77 and Route 102, about thirteen miles southeast of East Prairie. Its post office has closed, and mail now comes from East Prairie. The community was founded in 1899, and the name comes from the slang term "doreen", meaning money. About two miles south of here is the Dorena-Hickman Ferry which connects Route 77 with the Kentucky side of the Mississippi River.
Coordinates: 36°36′58″N 89°14′14″W / 36.61611°N 89.23722°W