Douglas Kell

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Douglas Kell
Carole Goble (CBE) and Douglas Kell (CBE) (13711397785).jpg
Douglas Kell at Buckingham Palace with Carole Goble after receiving his CBE
Born Douglas Bruce Kell
(1953-04-07) 7 April 1953 (age 61)[1]
Nationality United Kingdom
Fields
Institutions
Alma mater St John's College, Oxford
Thesis The Bioenergetics of Paracoccus denitrificans (1978)
Doctoral advisor
  • Stuart Ferguson[2]
  • Philip John
Doctoral students
Known for CEO of BBSRC
Notable awards
Website
dbkgroup.org
twitter.com/dbkell
manchester.ac.uk/research/douglas.kell

Douglas Bruce Kell CBE[19] FLSW (born 7 April 1953) is a British biochemist and Professor at the Manchester Institute of Biotechnology (MIB), part of the University of Manchester[20] and formerly Chief Executive Officer (CEO) of the Biotechnology and Biological Sciences Research Council (BBSRC).[21][22][23][24][25]

Education[edit]

He was educated at Hydneye House in Sussex,[26] Bradfield College in Berkshire and St John's College, Oxford. He graduated with a Bachelor of Arts in Biochemistry in 1975 and a Doctor of Philosophy (Oxon) in 1978 with a thesis on the Bioenergetics of Paracoccus denitrificans supervised by Stuart John Ferguson[2][27] and Philip John.[28]

From 1978 to 2002 he worked at Aberystwyth University, moving to UMIST in 2002 as EPSRC/RSC Research Chair in Bioanalytical Sciences.

Research[edit]

According to Google Scholar[29] his most cited peer-reviewed research papers are in functional genomics,[30] metabolomics[31] and the yeast genome.[32] He has also been involved in research to create a Robot Scientist[33] in collaboration with Ross King, Stephen Muggleton and Steve Oliver as well as several projects in systems biology[34][35][36][37][38]

Kell's research has been funded by the BBSRC and the Engineering and Physical Sciences Research Council.[39]

Awards and honours[edit]

Kell was appointed Commander of the Order of the British Empire (CBE) in the 2014 New Year Honours for services to science and research.[19]

Kell is also a Fellow of the Learned Society of Wales (FLSW), the Society of Biology (FSB) and the American Association for the Advancement of Science (FAAAS).

References[edit]

  1. ^ a b "KELL, Prof. Douglas Bruce" (Who's Who 2013, A & C Black, an imprint of Bloomsbury Publishing plc, 2013; online edn, Oxford University Press, Dec 2012). (subscription required)
  2. ^ a b Kell, D.; John, P.; Ferguson, S. (1978). "The protonmotive force in phosphorylating membrane vesicles from Paracoccus denitrificans. Magnitude, sites of generation and comparison with the phosphorylation potential". The Biochemical journal 174 (1): 257–266. PMC 1185905. PMID 212022. 
  3. ^ Zelena, Eva (2009). Application of ultra performance liquid chromatography mass spectrometry to metabolic profiling of human serum and plasma (PhD thesis). University of Manchester. 
  4. ^ Zelena, E.; Dunn, W. B.; Broadhurst, D.; Francis-Mcintyre, S.; Carroll, K. M.; Begley, P.; O'Hagan, S.; Knowles, J. D.; Halsall, A.; Husermet, I. D.; Wilson, D. B.; Kell, D. B. (2009). "Development of a Robust and Repeatable UPLC−MS Method for the Long-Term Metabolomic Study of Human Serum". Analytical Chemistry 81 (4): 1357–1364. doi:10.1021/ac8019366. PMID 19170513. 
  5. ^ Williamson, Thomas Charles (2009). Systems studies of the cAMP pathway and Glycolytic Oscillations in Saccharomyces cerevisiae (PhD thesis). University of Manchester. [dead link]
  6. ^ Williamson, T.; Schwartz, J. M.; Kell, D. B.; Stateva, L. (2009). "Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae". BMC Systems Biology 3: 70. doi:10.1186/1752-0509-3-70. PMC 2719611. PMID 19607691. 
  7. ^ Ihekwaba, Adaoha Elizabeth (2005). Modelling of cellular signal transduction process using numerical simulation techniques (PhD thesis). University of Manchester. [dead link]
  8. ^ Ihekwaba, A. E.; Broomhead, D. S.; Grimley, R. L.; Benson, N.; Kell, D. B. (2004). "Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kappaB pathway: The roles of IKK and IkappaBalpha". Systems biology 1 (1): 93–103. doi:10.1049/sb:20045009. PMID 17052119. 
  9. ^ Ihekwaba, A. E.; Broomhead, D. S.; Grimley, R.; Benson, N.; White, M. R.; Kell, D. B. (2005). "Synergistic control of oscillations in the NF-kappaB signalling pathway". Systems biology 152 (3): 153–160. doi:10.1049/ip-syb:20050050. PMID 16986278. 
  10. ^ Brown, Maria Cecilia (2006). Metabolic footprinting: computational analysis of post-genomic data (PhD thesis). University of Manchester. [dead link]
  11. ^ Brown, M.; Wedge, D. C.; Goodacre, R.; Kell, D. B.; Baker, P. N.; Kenny, L. C.; Mamas, M. A.; Neyses, L.; Dunn, W. B. (2011). "Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets". Bioinformatics 27 (8): 1108–1112. doi:10.1093/bioinformatics/btr079. PMC 3709197. PMID 21325300. 
  12. ^ Brown, M.; Dunn, W. B.; Dobson, P.; Patel, Y.; Winder, C. L.; Francis-Mcintyre, S.; Begley, P.; Carroll, K.; Broadhurst, D.; Tseng, A.; Swainston, N.; Spasic, I.; Goodacre, R.; Kell, D. B. (2009). "Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics". The Analyst 134 (7): 1322–1332. doi:10.1039/b901179j. PMID 19562197. 
  13. ^ Handl, Julia Karena (2006). Multiobjective approaches to the data-driven analysis of biological systems (PhD thesis). University of Manchester. [dead link]
  14. ^ Handl, J.; Kell, D. B.; Knowles, J. (2007). "Multiobjective Optimization in Bioinformatics and Computational Biology". IEEE/ACM Transactions on Computational Biology and Bioinformatics 4 (2): 279–292. doi:10.1109/TCBB.2007.070203. PMID 17473320. 
  15. ^ Handl, J.; Knowles, J.; Kell, D. B. (2005). "Computational cluster validation in post-genomic data analysis". Bioinformatics 21 (15): 3201–3212. doi:10.1093/bioinformatics/bti517. PMID 15914541. 
  16. ^ Mendes, Pedro Pedrosa (1994). Computer simulation of the dynamics of biochemical pathways (PhD thesis). University of Aberystwyth. 
  17. ^ "AAAS - 2012 Fellows". Archived from the original on 2012-02-18. 
  18. ^ "26 April 2012 - BBSRC Chief Executive elected as Fellow of the Learned Society of Wales - News - BBSRC". Archived from the original on 2012-04-27. 
  19. ^ a b c The London Gazette: (Supplement) no. 60728. p. 9. 31 December 2013.
  20. ^ "Prof Douglas Kell, research profile - personal details (The University of Manchester)". Retrieved 2012-06-12. 
  21. ^ "19 June 2012 - Reappointment of Chief Executive for the Biotechnology and Biological Sciences Research Council - News - BBSRC". Archived from the original on 2012-06-26. 
  22. ^ http://www.rsc.org/chemistryworld/News/2008/November/24110801.asp Douglas Kell interview
  23. ^ List of publications from Microsoft Academic Search
  24. ^ Interview with Douglas Kell on the website of the Royal Society of Chemistry
  25. ^ Douglas Kell from the ACM Portal
  26. ^ "Hydneye House - a set on Flickr". Archived from the original on 2013-04-25. 
  27. ^ "Prof Stuart Ferguson Page - Department of Biochemistry, University of Oxford". Archived from the original on 2013-04-25. 
  28. ^ Kelll, Douglas Bruce (1978). The bioenergetics of paracoccus denitrificans (PhD thesis). University of Oxford. 
  29. ^ List of publications from Google Scholar
  30. ^ Oliver, S. G.; Teusink, L. M.; Broadhurst, B.; Zhang, D.; Hayes, N.; Walsh, A.; Berden, M. C.; Brindle, J. A.; Kell, K. M.; Rowland, D. B.; Westerhoff, J. J.; Van Dam, H. V.; Oliver, K. (2001). "A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations". Nature Biotechnology 19 (1): 45–50. doi:10.1038/83496. PMID 11135551. 
  31. ^ Goodacre, R.; Vaidyanathan, S.; Dunn, W. B.; Harrigan, G. G.; Kell, D. B. (2004). "Metabolomics by numbers: Acquiring and understanding global metabolite data". Trends in Biotechnology 22 (5): 245–252. doi:10.1016/j.tibtech.2004.03.007. PMID 15109811. 
  32. ^ Oliver, S.; Winson, M.; Kell, D.; Baganz, F. (1998). "Systematic functional analysis of the yeast genome". Trends in Biotechnology 16 (9): 373–378. doi:10.1016/S0167-7799(98)01214-1. PMID 9744112. 
  33. ^ King, R. D.; Whelan, K. E.; Jones, F. M.; Reiser, P. G. K.; Bryant, C. H.; Muggleton, S. H.; Kell, D. B.; Oliver, S. G. (2004). "Functional genomic hypothesis generation and experimentation by a robot scientist". Nature 427 (6971): 247–252. doi:10.1038/nature02236. PMID 14724639. 
  34. ^ Kell, D. (2009). "Journal club: A systems biologist ponders how disparate ideas can sometimes come together beautifully". Nature 460 (7256): 669–669. Bibcode:2009Natur.460..669K. doi:10.1038/460669e. PMID 19661875. 
  35. ^ Dobson, P. D.; Smallbone, K.; Jameson, D.; Simeonidis, E.; Lanthaler, K.; Pir, P.; Lu, C.; Swainston, N.; Dunn, W. B.; Fisher, P.; Hull, D.; Brown, M.; Oshota, O.; Stanford, N. J.; Kell, D. B.; King, R. D.; Oliver, S. G.; Stevens, R. D.; Mendes, P. (2010). "Further developments towards a genome-scale metabolic model of yeast". BMC Systems Biology 4: 145. doi:10.1186/1752-0509-4-145. PMC 2988745. PMID 21029416. 
  36. ^ Pir, P.; Gutteridge, A.; Wu, J.; Rash, B.; Kell, D. B.; Zhang, N.; Oliver, S. G. (2012). "The genetic control of growth rate: A systems biology study in yeast". BMC Systems Biology 6: 4. doi:10.1186/1752-0509-6-4. PMC 3398284. PMID 22244311. 
  37. ^ List of publications from the DBLP Bibliography Server
  38. ^ Douglas Kell from the Scopus bibliographic database
  39. ^ http://gow.epsrc.ac.uk/NGBOViewPerson.aspx?PersonId=8693 Grants awarded to Douglas Kell] by the Engineering and Physical Sciences Research Council
Government offices
Preceded by
Julia Goodfellow
CEO of the Biotechnology and Biological Sciences Research Council
2008–2013
Succeeded by
Jackie Hunter