Drinabant

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Drinabant
Drinabant.svg
Systematic (IUPAC) name
(±)-N-{1-[bis(4-chlorophenyl)methyl]-3-azetidinyl}-N-(3,5-difluorophenyl)methanesulfonamide
Clinical data
Identifiers
358970-97-5
None
PubChem CID 10278470
ChemSpider 8453947
Chemical data
Formula C23H20Cl2F2N2O2S
497.385 g/mol

Drinabant (INN; AVE-1625) is a drug that acts as a selective CB1 receptor antagonist, which was under investigation varyingly by Sanofi-Aventis as a treatment for obesity, schizophrenia, Alzheimer's disease, Parkinson's disease, and nicotine dependence.[1][2][3] Though initially studied as a potential treatment for a variety of different medical conditions, Sanofi-Aventis eventually narrowed down the therapeutic indications of the compound to just appetite suppression. Drinabant reached phase IIb clinical trials for this purpose in the treatment of obesity but was shortly thereafter discontinued,[4] likely due to the observation of severe psychiatric side effects including anxiety, depression, and thoughts of suicide in patients treated with the now-withdrawn rimonabant, another CB1 antagonist that was also under development by Sanofi-Aventis.[5]

See also[edit]

References[edit]

  1. ^ Lange JH, Kruse CG (2008). "Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives". Chemical Record (New York, N.Y.) 8 (3): 156–68. doi:10.1002/tcr.20147. PMID 18563799. 
  2. ^ Kwon MO, Herrling P (2005). "List of drugs in development for neurodegenerative diseases. Update September 2005". Neuro-degenerative Diseases 2 (2): 61–108. doi:10.1159/000089285. PMID 16909049. 
  3. ^ Gerald Litwack (14 August 2009). Anandamide. Academic Press. p. 172. ISBN 978-0-12-374782-2. Retrieved 13 May 2012. 
  4. ^ Reggio, Patricia H. (2009). "Toward the design of cannabinoid CB1 receptor inverse agonists and neutral antagonists". Drug Development Research 70 (8). doi:10.1002/ddr.20337. ISSN 0272-4391. 
  5. ^ Lee HK, Choi EB, Pak CS (2009). "The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents". Current Topics in Medicinal Chemistry 9 (6): 482–503. doi:10.2174/156802609788897844. PMID 19689362.