Duesberg hypothesis

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The Duesberg hypothesis is the claim, associated with University of California, Berkeley, professor Peter Duesberg, that various noninfectious factors such as recreational and pharmaceutical drug use are the cause of AIDS, and that HIV (human immunodeficiency virus) is merely a harmless passenger virus.[1] The most prominent supporters of this hypothesis are Duesberg himself, biochemist and vitamin proponent David Rasnick, and journalist Celia Farber. The scientific community contends that Duesberg’s arguments are the result of cherry-picking predominantly outdated scientific data[2] and selectively ignoring evidence in favor of HIVs’ role in AIDS.[3] The scientific consensus is that the Duesberg hypothesis is incorrect and that HIV is the cause of AIDS.[4][5][6]

Role of legal and illegal drug use[edit]

Duesberg argues that there is a statistical correlation between trends in recreational drug use and trends in AIDS cases.[7] He argues that the epidemic of AIDS cases in the 1980s corresponds to a supposed epidemic of recreational drug use in the United States and Europe during the same time frame.

These claims are not supported by epidemiologic data. The average yearly increase in opioid-related deaths from 1990 to 2002 was nearly three times the yearly increase from 1979–90, with the greatest increase in 2000–02, yet AIDS cases and deaths fell dramatically during the mid-to-late-1990s.[8] Duesberg’s claim that recreational drug use, rather than HIV, was the cause of AIDS has been specifically examined and found to be false. Cohort studies have found that only HIV-positive drug users develop opportunistic infections; HIV-negative drug users do not develop such infections, indicating that HIV rather than drug use is the cause of AIDS.[4][9]

Duesberg has also argued that nitrite inhalants were the cause of the epidemic of Kaposi sarcoma (KS) in gay men. However, this argument has been described as an example of the fallacy of a statistical confounding effect;[10] it is now known that a herpesvirus, potentiated by HIV, is responsible for AIDS-associated KS.[11][12]

Moreover, in addition to recreational drugs, Duesberg argues that anti-HIV drugs such as zidovudine (AZT) can cause AIDS. Duesberg’s claim that antiviral medication causes AIDS is regarded as disproven by the scientific community. Placebo-controlled studies have found that AZT as a single agent produces modest and short-lived improvements in survival and delays the development of opportunistic infections; it certainly did not cause AIDS, which develops in both treated and untreated study patients. With the subsequent development of protease inhibitors and highly active antiretroviral therapy, numerous studies have documented the fact that anti-HIV drugs prevent the development of AIDS and substantially prolong survival, further disproving the claim that these drugs “cause” AIDS.[4]

Scientific study and rejection of Duesberg’s risk-AIDS hypothesis[edit]

Several studies have specifically addressed Duesberg’s claim that recreational drug abuse or sexual promiscuity were responsible for the manifestations of AIDS. An early study of his claims, published in Nature in 1993, found Duesberg’s drug abuse-AIDS hypothesis to have “no basis in fact.”[9]

A large prospective study followed a group of 715 homosexual men in the Vancouver, Canada, area; approximately half were HIV-seropositive or became so during the follow-up period, and the remainder were HIV-seronegative. After more than 8 years of follow-up, despite similar rates of drug use, sexual contact, and other supposed risk factors in both groups, only the HIV-positive group suffered from opportunistic infections. Similarly, CD4 counts dropped in the patients who were HIV-infected, but remained stable in the HIV-negative patients, despite similar rates of risk behavior.[13] The authors concluded that “the risk-AIDS hypothesis ... is clearly rejected by our data,” and that “the evidence supports the hypothesis that HIV-1 has an integral role in the CD4 depletion and progressive immune dysfunction that characterise AIDS.”[13]

Similarly, the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study (WIHS)—which between them observed more than 8,000 Americans—demonstrated that “the presence of HIV infection is the only factor that is strongly and consistently associated with the conditions that define AIDS.”[14] A 2008 study found that recreational drug use (including marijuana, cocaine, poppers, and amphetamines) had no effect on CD4 or CD8 T-cell counts, providing further evidence against a role of recreational drugs as a cause of AIDS.[15]

Current AIDS definitions[edit]

Duesberg argued in 1989 that a significant number of AIDS victims had died without proof of HIV infection.[16] However, with the use of modern culture techniques and polymerase chain reaction testing, HIV can be demonstrated in virtually all patients with AIDS.[4] Since AIDS is now defined partially by the presence of HIV, Duesberg claims it is impossible by definition to offer evidence that AIDS doesn’t require HIV. However, the first definitions of AIDS mentioned no cause and the first AIDS diagnoses were made before HIV was discovered. The addition of HIV positivity to surveillance criteria as an absolutely necessary condition for case reporting occurred only in 1993, after a scientific consensus was established that HIV caused AIDS.[17][18][19][20]

AIDS in Africa[edit]

According to the Duesberg hypothesis, AIDS is not found in Africa. What Duesberg calls “the myth of an African AIDS epidemic,”[21] among people"[22] exists for several reasons, including:

  • The need, according to Duesberg, of the CDC, the WHO, and other health organizations to justify their existences, resulting in their “manufacturing contagious plagues out of noninfectious medical conditions.”[23]
  • Media sensationalism, with stories that “helped shape the Western impression of an AIDS problem out of control,” resulting in high levels of funding.[21]
  • Willing participation in deception by local doctors who wish to take advantage of this aid money: “African doctors themselves participate in building the myth of the AIDS pandemic.”[24]
  • Confusion or incompetence on the part of African doctors: “Many common Third World diseases are confused with AIDS even if they are not part of its official definition.”[25]

Duesberg states that African AIDS cases are “a collection of long-established, indigenous diseases, such as chronic fevers, weight loss, alias “slim disease,” diarrhea, and tuberculosis”[1] that result from malnutrition and poor sanitation. African AIDS cases, though, have increased in the last three decades as HIV's prevalence has increased[26] but as malnutrition percentages[27] and poor sanitation have declined in many African regions.[28] In addition, while HIV and AIDS are more prevalent in urban than in rural settings in Africa,[29] malnutrition and poor sanitation are found more commonly in rural than in urban settings.[30]

According to Duesberg, common diseases are easily misdiagnosed as AIDS in Africa because “the diagnosis of African AIDS is arbitrary” and does not include HIV testing.[1] A definition of AIDS agreed upon in 1985 by the World Health Organization in Bangui did not require a positive HIV test, but since 1985, many African countries have added positive HIV tests to the Bangui criteria for AIDS or changed their definitions to match those of the U.S. Centers for Disease Control.[31] One of the reasons for using more HIV tests despite their expense is that, rather than overestimating AIDS as Duesberg suggests, the Bangui definition alone excluded nearly half of African AIDS patients.”[32]

Duesberg notes that diseases associated with AIDS differ between African and Western populations, concluding that the causes of immunodeficiency must be different. Tuberculosis is much more commonly diagnosed among AIDS patients in Africa than in Western countries, while PCP conforms to the opposite pattern.[33] Tuberculosis, though, had higher prevalence in Africa than in the West before the spread of HIV. In Africa and the United States, HIV has spurred a similar percentage increase in tuberculosis cases.[34] PCP may be underestimated in Africa: since machinery “required for accurate testing is relatively rare in many resource-poor areas, including large parts of Africa, PCP is likely to be underdiagnosed in Africa. Consistent with this hypothesis, studies that report the highest rates of PCP in Africa are those that use the most advanced diagnostic methods”[35] Duesberg also claims that Kaposi's Sarcoma is "exclusively diagnosed in male homosexual risk groups using nitrite inhalants and other psychoactive drugs as aphrodisiacs",[1] but the cancer is fairly common among heterosexuals in some parts of Africa,[36] and is found in heterosexuals in the United States as well.[37]

Because reported AIDS cases in Africa and other parts of the developing world include a larger proportion of people who do not belong to Duesberg’s preferred risk groups of drug addicts and male homosexuals,[38] Duesberg writes on his website that “There are no risk groups in Africa, like drug addicts and homosexuals.” However, many studies have addressed the issue of risk groups in Africa and concluded that the risk of AIDS is not equally distributed.[39][40] In addition, AIDS in Africa largely kills sexually active working-age adults.[41][42]

Duesberg claims that retroviruses like HIV must be harmless to survive[edit]

Duesberg argues that retroviruses like HIV must be harmless to survive: they do not kill cells and they do not cause cancer, he maintains. Duesberg writes, “retroviruses do not kill cells because they depend on viable cells for the replication of their RNA from viral DNA integrated into cellular DNA.”[1] Duesberg elsewhere states that “the typical virus reproduces by entering a living cell and commandeering the cell’s resources in order to make new virus particles, a process that ends with the disintegration of the dead cell.”[43]

Duesberg also rejects the involvement of retroviruses and other viruses in cancer. To him, virus-associated cancers are “freak accidents of nature” that do not warrant research programs such as the War on Cancer. Duesberg rejects a role in cancer for numerous viruses, including leukemia viruses, Epstein-Barr Virus, Human Papilloma Virus, Hepatitis B, Feline Leukemia Virus, and Human T-lymphotropic virus.[44]

Duesberg claims that the supposedly innocuous nature of all retroviruses is supported by what he considers to be their normal mode of proliferation: infection from mother to child in utero. Duesberg does not suggest that HIV is an endogenous retrovirus, a virus integrated into the germ line and genetically heritable:

...[a mother] provides her child with a nine-month continuous exposure to her blood and therefore has at least a 50 percent chance of passing HIV to the baby.[44]

Scientific response to the Duesberg hypothesis[edit]

The consensus in the scientific community is that the Duesberg hypothesis has been refuted by a large and growing mass of evidence showing that HIV causes AIDS, that the amount of virus in the blood correlates with disease progression, that a plausible mechanism for HIV’s action has been proposed, and that anti-HIV medication decreases mortality and opportunistic infection in people with AIDS.[4]

In the 9 December 1994 issue of Science (Vol. 266, No. 5191),[3] Duesberg’s methods and claims were evaluated in a group of articles. The authors concluded that

  • It is abundantly evident that HIV causes disease and death in hemophiliacs, a group generally lacking Duesberg's proposed risk factors.[4][45]
  • HIV fulfills Koch’s postulates, which are one set of criteria for demonstrating a causal relationship between a microbe and a disease.[46][47] (Subsequently, additional data further demonstrated the fulfillment of Koch's postulates.[48][49])
  • the AIDS epidemic in Thailand cited by Duesberg as confirmation of his hypothesis is in fact evidence of the role of HIV in AIDS.[50]
  • According to researchers who conducted large-scale studies of AZT, the drug does not cause AIDS. Furthermore, researchers acknowledged that recreational drugs do cause immune abnormalities, though not the type of immunodeficiency seen in AIDS.[51]

Effectiveness of antiretroviral medication[edit]

The vast majority of people with AIDS have never received antiretroviral drugs, including those in developed countries prior to the licensure of AZT (zidovudine) in 1987, and people in developing countries today where very few individuals have access to these medications.[52]

The NIAID reports that “in the mid-1980s, clinical trials enrolling patients with AIDS found that AZT given as single-drug therapy conferred a modest survival advantage compared [with] placebo. Among HIV-infected patients who had not yet developed AIDS, placebo-controlled trials found that AZT given as single-drug therapy delayed, for a year or two, the onset of AIDS-related illnesses. Significantly, long-term follow-up of these trials did not show a prolonged benefit of AZT, but also did not indicate that the drug increased disease progression or mortality. The lack of excess AIDS cases and death in the AZT arms of these placebo-controlled trials in effect counters the argument that AZT causes AIDS. Subsequent clinical trials found that patients receiving two-drug combinations had up to 50 percent improvements in time to progression to AIDS and in survival when compared with people receiving single-drug therapy. In more recent years, three-drug combination therapies have produced another 50 to 80 percent improvement in progression to AIDS and in survival when compared with two-drug regimens in clinical trials.”[53] "Use of potent anti-HIV combination therapies has contributed to dramatic reductions in the incidence of AIDS and AIDS-related deaths in populations where these drugs are widely available, an effect which clearly would not be seen if antiretroviral drugs caused AIDS."[4][54][55][56][57][58][59][60][61][62][63]

Opponents claim that nearly all HIV-positive people will develop AIDS[edit]

Duesberg claims as support for his idea that many drug-free HIV-positive people have not yet developed AIDS; HIV/AIDS scientists note that many drug-free HIV-positive people have developed AIDS, and that, in the absence of medical treatment or rare genetic factors postulated to delay disease progression, it is very likely that nearly all HIV-positive people will eventually develop AIDS. Scientists also note that HIV-negative drug users do not suffer from immune system collapse.[9]

See also[edit]

References[edit]

  1. ^ a b c d e Duesberg P, Koehnlein C, Rasnick D (2003). "The chemical bases of the various AIDS epidemics: recreational drugs, anti-viral chemotherapy and malnutrition". J Biosci 28 (4): 383–412. doi:10.1007/BF02705115. PMID 12799487. 
  2. ^ Galea P, Chermann JC. (1998). "HIV as the cause of AIDS and associated diseases". Genetica 104 (2): 133–142. doi:10.1023/A:1003432603348. PMID 10220906. 
  3. ^ a b Cohen, J. (1994). "The Duesberg phenomenon". Science 266 (5191): 1642–1644. Bibcode:1994Sci...266.1642C. doi:10.1126/science.7992043. PMID 7992043. 
  4. ^ a b c d e f g National Institutes of Allergy and Infectious Disease Fact Sheet: The Evidence that HIV Causes AIDS. Accessed via National Institutes of Health website on 9 March 2007.
  5. ^ Fact Sheets on HIV/AIDS, from the Centers for Disease Control. Retrieved 9 March 2007.
  6. ^ World Health Organization HIV and AIDS Programme, from the World Health Organization website. Retrieved 9 March 2007.
  7. ^ Duesberg P, Rasnick D (1998). "The AIDS dilemma: drug diseases blamed on a passenger virus". Genetica 104 (2): 85–132. doi:10.1023/A:1003405220186. PMID 10220905. 
  8. ^ Paulozzi LJ, Budnitz DS, Yongli X (2006). "Increasing deaths from opioid analgesics in the United States". Pharmacoepidemiology and Drug Safety 15 (9): 618–27. doi:10.1002/pds.1276. PMID 16862602. 
  9. ^ a b c Ascher MS, Sheppard HW, Winkelstein W, Vittinghoff E (1993). "Does drug use cause AIDS?". Nature 362 (6416): 103–4. Bibcode:1993Natur.362..103A. doi:10.1038/362103a0. PMID 8095697. 
  10. ^ Morabia A (1995). "Poppers, Kaposi's sarcoma, and HIV infection: empirical example of a strong confounding effect?". Prev Med 24 (1): 90–5. doi:10.1006/pmed.1995.1014. PMID 7661947. 
  11. ^ Kedes D, Operskalski E, Busch M, Kohn R, Flood J, Ganem D (1996). "The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission". Nat Med 2 (8): 918–24. doi:10.1038/nm0896-918. PMID 8705863. 
  12. ^ Martin J, Ganem D, Osmond D, Page-Shafer K, Macrae D, Kedes D (1998). "Sexual transmission and the natural history of human herpesvirus 8 infection". N Engl J Med 338 (14): 948–54. doi:10.1056/NEJM199804023381403. PMID 9521982. 
  13. ^ a b Schechter M, Craib K, Gelmon K, Montaner J, Le T, O'Shaughnessy M (1993). "HIV-1 and the aetiology of AIDS.". Lancet 341 (8846): 658–9. doi:10.1016/0140-6736(93)90421-C. PMID 8095571. 
  14. ^ MACS and WIHS Studies Provide Overwhelming Evidence That HIV Causes AIDS. From the National Institute of Allergy and Infectious Diseases. Retrieved 9 March 2007.
  15. ^ Chao C, Jacobson LP, Tashkin D et al. (2008). "Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men". Drug Alcohol Depend 94 (1–3): 165–171. doi:10.1016/j.drugalcdep.2007.11.010. PMC 2691391. PMID 18180115. 
  16. ^ Duesberg P (1989). "Human immunodeficiency virus and acquired immunodeficiency syndrome: correlation but not causation". Proc Natl Acad Sci USA 86 (3): 755–64. Bibcode:1989PNAS...86..755D. doi:10.1073/pnas.86.3.755. PMC 286556. PMID 2644642. 
  17. ^ [Centers for Disease Control and Prevention, Morbidity and Mortality Weekly Report, 31(37), 24 Sep 1982] Update on Acquired Immunodeficiency Syndrome (AIDS), United States.
  18. ^ [Centers for Disease Control and Prevention, Morbidity and Mortality Weekly Report, 34(25), 28 June 1985] Revision of the CDC Surveillance Case Definition of Acquired Immunodeficiency Syndrome for National Reporting, United States.
  19. ^ [Centers for Disease Control and Prevention, Morbidity and Mortality Weekly Report, 36(S1), 14 August 1987] Revision of the CDC Surveillance Case Definition for Acquired Immunodeficiency Syndrome.
  20. ^ [Centers for Disease Control and Prevention, Morbidity and Mortality Weekly Report, 41(RR-17), 18 December 1992] 1993 Revised Classification System for HIV Infection and Expanded Surveillance Definition for AIDS Among Adolescents and Adults.
  21. ^ a b [Duesberg P "Inventing the AIDS Virus" Regnery, 1997. ISBN 0-89526-399-8] Page 291.
  22. ^ Discover Magazine feature on Duesberg. Jeanne Linzer, Discover, 15 May 2008, AIDS "Dissident" Seeks Redemption...and a Cure for Cancer. Accessed 16 May 2008.
  23. ^ [Duesberg P "Inventing the AIDS Virus" Regnery, 1997. ISBN 0-89526-399-8] Page 137.
  24. ^ [Duesberg P "Inventing the AIDS Virus" Regnery, 1997. ISBN 0-89526-399-8] Pages 290-1.
  25. ^ [Duesberg P "Inventing the AIDS Virus" Regnery, 1997. ISBN 0-89526-399-8] Page 293.
  26. ^ Boerma, JT; Nunn, AJ; Whitworth, JA (1998). "Mortality impact of the AIDS epidemic: evidence from community studies in less developed countries". AIDS (London, England). 12 Suppl 1: S3–14. PMID 9677185. 
  27. ^ Figure of malnutrition percentage decreases Accessed 2 May 2008.
  28. ^ [1] Accessed 2 May 2008.
  29. ^ "HIV prevalence (%) by gender and urban/rural residence, selected sub-Saharan African countries, 2001-2005 From UNAIDS Joint United Nations Programme on HIV/AIDS. Retrieved 2 May 2008.
  30. ^ Fotso JC (2006). "Urban-rural differentials in child malnutrition: trends and socioeconomic correlates in sub-Saharan Africa". Health Place 13 (1): 205–23. doi:10.1016/j.healthplace.2006.01.004. PMID 16563851. 
  31. ^ [2] From the World Health Organization Accessed 1 May 2008.
  32. ^ Diaz T, De Cock K et al. (2005). "New strategies for HIV surveillance in resource-constrained settings: an overview". AIDS 19 (Suppl2): S1–S8. doi:10.1097/01.aids.0000172871.80723.3e. PMID 15930836. 
  33. ^ Cohen, J (2000). "Is AIDS in Africa a distinct disease?". Science 288 (5474): 2153–5. doi:10.1126/science.288.5474.2153. PMID 10896593. 
  34. ^ Corbett EL, Watt CJ et al. (2003). "The growing burden of tuberculosis: global trends and interactions with the HIV epidemic". Arch Intern Med 163 (9): 1009–21. doi:10.1001/archinte.163.9.1009. PMID 12742798. 
  35. ^ Science Outsold? Correcting the Falsehoods of "Science Sold Out: Does HIV Really Cause AIDS?" Page 15. Retrieved 1 May 2008.
  36. ^ Chokunonga, E; Levy, LM; Bassett, MT; Borok, MZ; Mauchaza, BG; Chirenje, MZ; Parkin, DM (1999). "Aids and cancer in Africa: the evolving epidemic in Zimbabwe". AIDS (London, England) 13 (18): 2583–8. doi:10.1097/00002030-199912240-00012. PMID 10630528. 
  37. ^ Hiatt KM, Nelson AM et al. (2008). "Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma". Modern Pathology 21 (5): 572–82. doi:10.1038/modpathol.2008.15. PMID 18376387. 
  38. ^ Sub-Saharan Africa From HIV InSite at the University of California, San Francisco. Retrieved 2 May 2008.
  39. ^ Wade AS, Kane CT et al. (2005). "HIV infection and sexually transmitted infections among men who have sex with men in Senegal". AIDS 19 (18): 2133–40. doi:10.1097/01.aids.0000194128.97640.07. PMID 16284463.  One recent article on AIDS and men who have sex with men (MSM).
  40. ^ Beyrer C (2007). "HIV epidemiology update and transmission factors: risks and risk contexts--16th International AIDS Conference epidemiology plenary". Clin Infect Dis 44 (7): 981–7. doi:10.1086/512371. PMID 17342654.  A recent article on various risk groups and risk factors in Africa.
  41. ^ Nunn, AJ; Mulder, DW; Kamali, A; Ruberantwari, A; Kengeya-Kayondo J-F, Whitworth J.; Whitworth, J (1997). "Mortality associated with HIV-1 infection over five years in a rural Ugandan population: cohort study". BMJ 315 (7111): 767–771. doi:10.1136/bmj.315.7111.767. PMC 2127535. PMID 9345167. 
  42. ^ Borgdorff, MW; Barongo, LR; Klokke, AH; Newell, JN; Senkoro, KP; Velema, JP; Gabone, RM. (1995). "HIV-1 incidence and HIV-1 associated mortality in a cohort of urban factory workers in Tanzania". Genitourin Med. 71 (4): 212–215. doi:10.1136/sti.71.4.212. PMC 1195515. PMID 7590710. 
  43. ^ [Duesberg P "Inventing the AIDS Virus" Regnery, 1997. ISBN 0-89526-399-8] Page 90.
  44. ^ a b Duesberg P "Inventing the AIDS Virus" Regnery, 1997. ISBN 0-89526-399-8
  45. ^ Cohen, J. (1994a). "Duesberg and critics agree: Hemophilia is the best test". Science 266 (5191): 1645–1646. Bibcode:1994Sci...266.1645C. doi:10.1126/science.7992044. PMID 7992044. 
  46. ^ Cohen, J. (1994b). "Fulfilling Koch's postulates". Science 266 (5191): 1647. doi:10.1126/science.7992045. PMID 7992045. 
  47. ^ Harden V (1992). "Koch's postulates and the etiology of AIDS: an historical perspective". Hist Philos Life Sci 14 (2): 249–69. PMID 1342726.  Full text available from National Institutes of Health website.
  48. ^ O'Brien, SJ; Goedert, JJ (1996). "HIV causes AIDS: Koch's postulates fulfilled". Current opinion in immunology 8 (5): 613–8. doi:10.1016/S0952-7915(96)80075-6. PMID 8902385.  edit
  49. ^ Chigwedere, P.; Essex, M. (2010). "AIDS Denialism and Public Health Practice". AIDS and Behavior 14 (2): 237–247. doi:10.1007/s10461-009-9654-7. PMID 20058063.  edit
  50. ^ Cohen, J. (1994c). "The epidemic in Thailand". Science 266 (5191): 1647. doi:10.1126/science.7992046. PMID 7992046. 
  51. ^ Cohen, J. (1994d). "Could drugs, rather than a virus be the cause of AIDS?". Science 266 (5191): 1648–1649. Bibcode:1994Sci...266.1648C. doi:10.1126/science.7992047. PMID 7992047. 
  52. ^ UNAIDS, 2003.
  53. ^ HHS, 2005
  54. ^ Palella, FJ Jr; Delaney, KM; Moorman, AC; Loveless, MO; Fuhrer, J; Satten, GA; Aschman, DJ; Holmberg, SD. (1998). "Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators". N. Engl. J. Med. 338 (13): 853–860. doi:10.1056/NEJM199803263381301. PMID 9516219. 
  55. ^ Mocroft, A; Vella, S; Benfield, TL; Chiesi, A; Miller, V; Gargalianos, P; Arminio Monforte, A; Yust, I; Bruun, JN et al. (1998). "Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group". Lancet 352 (9142): 1725–1730. doi:10.1016/S0140-6736(98)03201-2. PMID 9848347. 
  56. ^ Mocroft, A; Katlama, C; Johnson, AM; Pradier, C; Antunes, F; Mulcahy, F; Chiesi, A; Phillips, AN; Kirk, O et al. (2000). "AIDS across Europe, 1994-98: the EuroSIDA study". Lancet 356 (9226): 291–296. doi:10.1016/S0140-6736(00)02504-6. PMID 11071184. 
  57. ^ Vittinghoff, E; Scheer, S; O'Malley, P; Colfax, G; Holmberg, SD; Buchbinder, SP. (1999). "Combination antiretroviral therapy and recent declines in AIDS incidence and mortality". J. Infect. Dis. 179 (3): 717–720. doi:10.1086/314623. PMID 9952385. 
  58. ^ Detels, R; Munoz, A; McFarlane, G; Kingsley, LA; Margolick, JB; Giorgi, J; Schrager, LK; Phair, JP. (1998). "Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS Cohort Study Investigators". JAMA 280 (17): 1497–1503. doi:10.1001/jama.280.17.1497. PMID 9809730. 
  59. ^ De Martino, M; Tovo, PA; Balducci, M; Galli, L; Gabiano, C; Rezza, G; Pezzotti, P (2000). "Reduction in mortality with availability of antiretroviral therapy for children with perinatal HIV-1 infection. Italian Register for HIV Infection in Children and the Italian National AIDS Registry". JAMA: the Journal of the American Medical Association 284 (2): 190–7. doi:10.1001/jama.284.2.190. PMID 10889592. 
  60. ^ Hogg, RS; Yip, B; Kully, C; Craib, KJ; O'Shaughnessy, MV; Schechter, MT; Montaner, JS. (1999). "Improved survival among HIV-infected patients after initiation of triple-drug antiretroviral regimens". CMAJ 160 (5): 659–665. PMC 1230111. PMID 10102000. 
  61. ^ Schwarcz, SK; Hsu, LC; Vittinghoff, E; Katz, MH. (2000). "Impact of protease inhibitors and other antiretroviral treatments on acquired immunodeficiency syndrome survival in San Francisco, California, 1987-1996". Am J Epidem 152 (2): 178–185. doi:10.1093/aje/152.2.178. PMID 10909955. 
  62. ^ Kaplan, JE; Hanson, D; Dworkin, MS; Frederick, T; Bertolli, J; Lindegren, ML; Holmberg, S; Jones, JL (2000). "Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy". Clinical Infectious Diseases. 30 Suppl 1: S5–14. doi:10.1086/313843. PMID 10770911. 
  63. ^ McNaghten, AD; Hanson, DL; Jones, JL; Dworkin, MS; Ward, JW.; The Adultadolescent Spectrum Of Disease Group +/ (1999). "Effects of antiretroviral therapy and opportunistic illness primary chemoprophylaxis on survival after AIDS diagnosis. Adult/Adolescent Spectrum of Disease Group". AIDS 13 (13): 1687–1695. doi:10.1097/00002030-199909100-00012. PMID 10509570. 

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