Bravo made his first-class debut for Trinidad and Tobago against Barbados in 2002, opening the innings and scoring 15 and 16 but not bowling. He scored his maiden first-class century a month later and was included in the West Indies A squad for their tour of England in 2002. In early 2003 he scored another century but it was a spell of bowling in which he took 6–11 against the Windward Islands that brought him to prominence as an all-rounder.
Bravo made his One Day International debut against England in their 2003/04 tour of the Caribbean, in a match in which he failed to bat but took 2–31 with the ball. In the West Indies tour of England in 2004 Bravo made his Test debut when he was selected for the First Test at Lord's in which he scored 44 and 10 and took three wickets. He finished the Test series with 16 wickets and a total of 220 runs with his most impressive performance at Old Trafford in a match in which he was the top scorer in the first innings with 77 followed by a 6 for 55 performance with the ball. The latter remains his best bowling figures in Test cricket.
During a Test series against South Africa in 2005, Bravo scored his maiden century – 107 before getting out to Mark Boucher – in the fourth Test in Antigua, but that was overshadowed when he accused South African Graeme Smith of directing a racist comment at him. At the subsequent hearing no evidence could be found and charges were dropped against Smith, who immediately demanded an apology from Bravo. Bravo, backed by the West Indies Cricket Board, refused to do so and received a hail of criticism from an indignant South African press while finding support at home as a human rights campaigner.
On the West Indies tour of Australia in 2005, Bravo was controversially not picked for the first Test at Brisbane in which the West Indies were beaten convincingly. He was recalled for the second Test in Hobart and made a superb 113, after coming in at a very difficult stage for the West Indies. His innings lifted the West Indies and helped them regain some pride, forcing the Australians to bat for a second time in the match. In the third and final match of the series at Adelaide, he bowled a superb spell in the Australians first innings taking 6 for 84 including the
In West Indies tour of New Zealand in early 2006 Bravo strained his left side in the Twenty20 game at the start of the tour and was unable to bowl but still played in all three tests as a specialist batsman. His selection showed how far he had come in the previous two years and how crucial he had become to the West Indies team.
After a disappointing series in India Bravo returned to top form in the ICC Champions Trophy 2006 when he took 7 wickets at an average of 27.57 and scored 164 runs at an average of 41 although most of the runs were scored in a dead rubber with England in which he made his first ever ODI century scoring a majestic 112 not out as part of a second wicket stand of 174 with Chris Gayle. His bowling contained some lethal slower-paced yorkers with which he dismissed Michael Clarke and Chris Read.
Bravo had a disappointing 2007 World Cup scoring 129 runs at an average of 21.50 and although he took 13 wickets at 27.76 his economy rate was 5.56. Against South Africa he conceded 69 runs off 7 overs including 18 off his first over.
During the Third Test against England at Old Trafford on 9 June 2007, Bravo acted as an emergency wicket-keeper in place of Denesh Ramdin who had gone off for treatment after being hit on the head with the ball. In the same Test he took the wicket of England batsman Kevin Pietersen with a bouncer which struck the batsman's helmet knocking the helmet off of his head onto the stumps and dislodging the bails causing Pietersen to be given out hit wicket.
He was one of the top performing players in the 2012 IPL playing for Chennai Super Kings scoring 461 runs at an average of 46 off a strike rate of 140. He was also the team's highest wicket taker with 19 wickets.
He also performed well in the 2013 IPL playing for Chennai Super Kings, taking 32 wickets at an average of 15.0 to win the Purple Cap and overthrow Albie Morkel to become Chennai Super Kings's leading wicket taker.
During IPL 2014 he sustained a shoulder injury in the first match against Kings XI Punjab and has been subsequently ruled out of the remaining matches.
Dwayne Bravo was ruled out from the World Cup 2011 outfit due to the knee injury when he slipped at the wicket while bowling to South African batsman on 24 February at Delhi. He was rested for four weeks and could not participate further in the tournament.
He holds the record for the world's best bowling figures in an ODI match as a captain in a bilateral series
he holds the record for the world's best bowling average(runs conceded per wicket taken) and bowling strike rate(number of balls bowled to take a wicket) as a captain in a bilateral series(among those who have taken 10 or more wickets in the same series)
Shares the record along with another five cricketers to take a five-wicket haul in an ODI match as a captain in a bilateral series.