Dyschromatosis symmetrica hereditaria

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Dyschromatosis symmetrica hereditaria (also known as "Reticulate acropigmentation of Dohi," and "Symmetrical dyschromatosis of the extremities") is a rare autosomally inherited dermatosis. It is characterized by progressively pigmented and depigmented macules, often mixed in a reticulate pattern, concentrated on the dorsal extremities.[1]:855 It presents primarily in the Japanese, but has also been found to affect individuals from Europe, India and the Caribbean.

Genetics[edit]

This disease is caused by mutation in the double stranded RNA specific adenosine deaminase (ADAR1) gene.[2] This gene is located on the long arm of chromosome 1 (1q21)

See also[edit]

References[edit]

  1. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  2. ^ Zhang GL, Shi HJ, Shao MH, Li M, Mu HJ, Gu Y, Du XF, Xie P (2013) Mutations in the ADAR1 gene in 2 Chinese families with dyschromatosis symmetrica hereditaria. Genet Mol Res 12(AOP)