E2F2

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E2F transcription factor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols E2F2 ; E2F-2
External IDs OMIM600426 MGI1096341 HomoloGene48264 GeneCards: E2F2 Gene
Orthologs
Species Human Mouse
Entrez 1870 242705
Ensembl ENSG00000007968 ENSMUSG00000018983
UniProt Q14209 P56931
RefSeq (mRNA) NM_004091 NM_177733
RefSeq (protein) NP_004082 NP_808401
Location (UCSC) Chr 1:
23.83 – 23.86 Mb
Chr 4:
136.17 – 136.2 Mb
PubMed search [1] [2]

Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.[1][2]

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.[3]

Interactions[edit]

E2F2 has been shown to interact with BRD2,[4][5] Retinoblastoma protein[6] and RYBP.[7]

See also[edit]

References[edit]

  1. ^ Ivey-Hoyle M, Conroy R, Huber HE, Goodhart PJ, Oliff A, Heimbrook DC (January 1994). "Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F". Mol Cell Biol 13 (12): 7802–12. PMC 364852. PMID 8246995. 
  2. ^ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (January 1994). "The retinoblastoma protein binds to a family of E2F transcription factors". Mol Cell Biol 13 (12): 7813–25. PMC 364853. PMID 8246996. 
  3. ^ "Entrez Gene: E2F2 E2F transcription factor 2". 
  4. ^ Crowley, Thomas E; Kaine Emily M; Yoshida Manabu; Nandi Anindita; Wolgemuth Debra J (August 2002). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. (United States) 16 (8): 1727–37. doi:10.1210/me.2001-0353. ISSN 0888-8809. PMID 12145330. 
  5. ^ Denis, G V; Vaziri C; Guo N; Faller D V (August 2000). "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F". Cell Growth Differ. (UNITED STATES) 11 (8): 417–24. ISSN 1044-9523. PMID 10965846. 
  6. ^ Lee, Changwook; Chang Jeong Ho; Lee Hyun Sook; Cho Yunje (December 2002). "Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor". Genes Dev. (United States) 16 (24): 3199–212. doi:10.1101/gad.1046102. ISSN 0890-9369. PMC 187509. PMID 12502741. 
  7. ^ Schlisio, Susanne; Halperin Terri; Vidal Miguel; Nevins Joseph R (November 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. (England) 21 (21): 5775–86. doi:10.1093/emboj/cdf577. ISSN 0261-4189. PMC 131074. PMID 12411495. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.