E2F2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
E2F transcription factor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols E2F2 ; E2F-2
External IDs OMIM600426 MGI1096341 HomoloGene48264 GeneCards: E2F2 Gene
Orthologs
Species Human Mouse
Entrez 1870 242705
Ensembl ENSG00000007968 ENSMUSG00000018983
UniProt Q14209 P56931
RefSeq (mRNA) NM_004091 NM_177733
RefSeq (protein) NP_004082 NP_808401
Location (UCSC) Chr 1:
23.83 – 23.86 Mb
Chr 4:
136.17 – 136.2 Mb
PubMed search [1] [2]

Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.[1][2]

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.[3]

Interactions[edit]

E2F2 has been shown to interact with BRD2,[4][5] Retinoblastoma protein[6] and RYBP.[7]

See also[edit]

References[edit]

  1. ^ Ivey-Hoyle M, Conroy R, Huber HE, Goodhart PJ, Oliff A, Heimbrook DC (January 1994). "Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F". Mol Cell Biol 13 (12): 7802–12. PMC 364852. PMID 8246995. 
  2. ^ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (January 1994). "The retinoblastoma protein binds to a family of E2F transcription factors". Mol Cell Biol 13 (12): 7813–25. PMC 364853. PMID 8246996. 
  3. ^ "Entrez Gene: E2F2 E2F transcription factor 2". 
  4. ^ Crowley, Thomas E; Kaine Emily M, Yoshida Manabu, Nandi Anindita, Wolgemuth Debra J (August 2002). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. (United States) 16 (8): 1727–37. doi:10.1210/me.2001-0353. ISSN 0888-8809. PMID 12145330. 
  5. ^ Denis, G V; Vaziri C, Guo N, Faller D V (August 2000). "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F". Cell Growth Differ. (UNITED STATES) 11 (8): 417–24. ISSN 1044-9523. PMID 10965846. 
  6. ^ Lee, Changwook; Chang Jeong Ho, Lee Hyun Sook, Cho Yunje (December 2002). "Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor". Genes Dev. (United States) 16 (24): 3199–212. doi:10.1101/gad.1046102. ISSN 0890-9369. PMC 187509. PMID 12502741. 
  7. ^ Schlisio, Susanne; Halperin Terri, Vidal Miguel, Nevins Joseph R (November 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. (England) 21 (21): 5775–86. doi:10.1093/emboj/cdf577. ISSN 0261-4189. PMC 131074. PMID 12411495. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.