E2F4

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E2F transcription factor 4, p107/p130-binding
Protein E2F4 PDB 1cf7.png
PDB rendering based on 1cf7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols E2F4 ; E2F-4
External IDs OMIM600659 MGI103012 HomoloGene1471 GeneCards: E2F4 Gene
RNA expression pattern
PBB GE E2F4 38707 r at tn.png
PBB GE E2F4 202248 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1874 104394
Ensembl ENSG00000205250 ENSMUSG00000014859
UniProt Q16254 Q8R0K9
RefSeq (mRNA) NM_001950 NM_148952
RefSeq (protein) NP_001941 NP_683754
Location (UCSC) Chr 16:
67.23 – 67.23 Mb
Chr 8:
105.3 – 105.31 Mb
PubMed search [1] [2]

Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene.[1][2]

Function[edit]

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.[3]

Structure[edit]

The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids (Asp + Glu), and a tumor suppressor protein association domain which is embedded within the transactivation domain.

Interactions[edit]

E2F4 has been shown to interact with Smad3.[4]

See also[edit]

References[edit]

  1. ^ Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM (Dec 1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107". Genes Dev 8 (22): 2665–79. doi:10.1101/gad.8.22.2665. PMID 7958924. 
  2. ^ Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (Apr 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proc Natl Acad Sci U S A 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279. 
  3. ^ "Entrez Gene: E2F4 E2F transcription factor 4, p107/p130-binding". 
  4. ^ Chen CR, Kang Y, Siegel PM, Massagué J (July 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression". Cell 110 (1): 19–32. doi:10.1016/S0092-8674(02)00801-2. PMID 12150994. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.