E2 (HCV)

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HCV genome

E2 is a viral structural protein found in the hepatitis C virus.[1][2] It is present on the viral membrane and functions as a host receptor binding protein, mediating entry into host cells. Therefore, it is a key target for the design of entry inhibitors and vaccine immunogens.


  1. ^ Garcia JE, Puentes A, Súarez J et al. (February 2002). "Hepatitis C virus (HCV) E1 and E2 protein regions that specifically bind to HepG2 cells". J. Hepatol. 36 (2): 254–62. doi:10.1016/S0168-8278(01)00262-8. PMID 11830338. 
  2. ^ Bartosch B, Dubuisson J, Cosset FL (March 2003). "Infectious Hepatitis C Virus Pseudo-particles Containing Functional E1–E2 Envelope Protein Complexes". J. Exp. Med. 197 (5): 633–42. doi:10.1084/jem.20021756. PMC 2193821. PMID 12615904.