EAF2

ELL associated factor 2
Identifiers
Symbols	EAF2; BM040; TRAITS; U19
External IDs	OMIM: 607659 HomoloGene: 10208 GeneCards: EAF2 Gene
Gene Ontology Molecular function • protein binding Cellular component • nucleus • nucleoplasm • nucleolus • nuclear speck Biological process • apoptotic process • induction of apoptosis • negative regulation of cell growth • positive regulation of transcription, DNA-dependent • negative regulation of epithelial cell proliferation involved in prostate gland development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55840	n/a
Ensembl	ENSG00000145088	n/a
UniProt	Q96CJ1	n/a
RefSeq (mRNA)	NM_018456.4	n/a
RefSeq (protein)	NP_060926.2	n/a
Location (UCSC)	Chr 3: 121.55 – 121.61 Mb	n/a
PubMed search	[1]	n/a

ELL-associated factor 2 is a protein that in humans is encoded by the EAF2 gene.

Further reading

• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Saso K, Ito T, Natori S, Sekimizu K (2004). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II". J. Biochem. 133 (4): 493–500. doi:10.1093/jb/mvg065. PMID 12761297. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Kong SE, Banks CA, Shilatifard A, et al. (2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proc. Natl. Acad. Sci. U.S.A. 102 (29): 10094–8. doi:10.1073/pnas.0503017102. PMC 1177379. PMID 16006523. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1177379. 
• Xiao W, Jiang F, Wang Z (2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". Prostate 66 (1): 1–12. doi:10.1002/pros.20309. PMID 16114057. 
• Jiang F, Ai J, Xiao W, Wang Z (2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Lett. 253 (2): 265–72. doi:10.1016/j.canlet.2007.02.003. PMC 1989770. PMID 17395368. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1989770.