EBI3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Epstein-Barr virus induced 3
Identifiers
Symbols EBI3 ; IL-27B; IL27B
External IDs OMIM605816 MGI1354171 HomoloGene4207 GeneCards: EBI3 Gene
RNA expression pattern
PBB GE EBI3 219424 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10148 50498
Ensembl ENSG00000105246 ENSMUSG00000003206
UniProt Q14213 O35228
RefSeq (mRNA) NM_005755 NM_015766
RefSeq (protein) NP_005746 NP_056581
Location (UCSC) Chr 19:
4.23 – 4.24 Mb
Chr 17:
55.95 – 55.96 Mb
PubMed search [1] [2]

Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the EBI3 gene.[1][2]

Function[edit]

This gene was identified by the induction of its expression in B lymphocytes by Epstein-Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.[3]

EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells.[4] IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.[5][3]

References[edit]

  1. ^ "Entrez Gene: EBI3 Epstein-Barr virus induced gene 3". 
  2. ^ Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. PMC 189923. PMID 8551575. 
  3. ^ a b Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA (November 2007). "The inhibitory cytokine IL-35 contributes to regulatory T-cell function". Nature 450 (7169): 566–9. doi:10.1038/nature06306. PMID 18033300. 
  4. ^ Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N (September 2006). "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells". Nat. Immunol. 7 (9): 929–36. doi:10.1038/ni1375. PMID 16906167. 
  5. ^ Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY (November 2007). "IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells". Eur. J. Immunol. 37 (11): 3021–9. doi:10.1002/eji.200737810. PMID 17874423. 

Further reading[edit]

External links[edit]