ECGF1

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Thymidine phosphorylase
Protein ECGF1 PDB 1uou.png
PDB rendering based on 1uou.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TYMP ; ECGF; ECGF1; MEDPS1; MNGIE; MTDPS1; PDECGF; TP; hPD-ECGF
External IDs OMIM131222 MGI1920212 HomoloGene1474 ChEMBL: 3106 GeneCards: TYMP Gene
EC number 2.4.2.4
RNA expression pattern
PBB GE ECGF1 204858 s at tn.png
PBB GE ECGF1 205241 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1890 72962
Ensembl ENSG00000025708 ENSMUSG00000022615
UniProt P19971 Q99N42
RefSeq (mRNA) NM_001113755 NM_138302
RefSeq (protein) NP_001107227 NP_612175
Location (UCSC) Chr 22:
50.96 – 50.97 Mb
Chr 15:
89.37 – 89.38 Mb
PubMed search [1] [2]

Thymidine phosphorylase is an enzyme that in humans is encoded by the TYMP gene.[1][2]

Platelet-derived endothelial cell growth factor (ECGF1) is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells.

Because it limits glial cell proliferation, ECGF1 is also known as thymidine phosphorylase and as gliostatin. The ECGF1 gene contains 10 exons spanning more than 4.3 kb. Thymidine phosphorylase activity of ECGF1 in leukocytes from mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) patients was less than 5 percent of controls, indicating that loss-of-function mutations in thymidine phosphorylase cause MNGIE.[3]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". 

References[edit]

  1. ^ Usuki K, Saras J, Waltenberger J, Miyazono K, Pierce G, Thomason A, Heldin CH (Jun 1992). "Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity". Biochem Biophys Res Commun 184 (3): 1311–6. doi:10.1016/S0006-291X(05)80025-7. PMID 1590793. 
  2. ^ Spinazzola A, Marti R, Nishino I, Andreu AL, Naini A, Tadesse S, Pela I, Zammarchi E, Donati MA, Oliver JA, Hirano M (Feb 2002). "Altered thymidine metabolism due to defects of thymidine phosphorylase". J Biol Chem 277 (6): 4128–33. doi:10.1074/jbc.M111028200. PMID 11733540. 
  3. ^ "Entrez Gene: ECGF1 endothelial cell growth factor 1 (platelet-derived)". 

External links[edit]

Further reading[edit]