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Extracellular matrix protein 1
Symbols ECM1 ; URBWD
External IDs OMIM602201 MGI103060 HomoloGene3260 GeneCards: ECM1 Gene
RNA expression pattern
PBB GE ECM1 209365 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1893 13601
Ensembl ENSG00000143369 ENSMUSG00000028108
UniProt Q16610 Q61508
RefSeq (mRNA) NM_001202858 NM_001252653
RefSeq (protein) NP_001189787 NP_001239582
Location (UCSC) Chr 1:
150.48 – 150.49 Mb
Chr 3:
95.73 – 95.74 Mb
PubMed search [1] [2]

Extracellular matrix protein 1 is a protein that in humans is encoded by the ECM1 gene.[1][2][3]

This gene encodes an extracellular protein containing motifs with a cysteine pattern characteristic of the cysteine pattern of the ligand-binding "double-loop" domains of the albumin protein family. This gene maps outside of the epidermal differentiation complex (EDC), a cluster of three gene families involved in epidermal differentiation. Alternatively spliced transcript variants encoding distinct isoforms have been described.[3]


ECM1 is implicated in breast cancer, thyroid cancer, hepatocellular carcinoma, and other cancers, and also in lipoid proteinosis and ulcerative colitis[4] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology,[5]).

See also[edit]


  1. ^ Smits P, Ni J, Feng P, Wauters J, Van Hul W, Boutaibi ME, Dillon PJ, Merregaert J (Jan 1998). "The human extracellular matrix gene 1 (ECM1): genomic structure, cDNA cloning, expression pattern, and chromosomal localization". Genomics 45 (3): 487–95. doi:10.1006/geno.1997.4918. PMID 9367673. 
  2. ^ Johnson MR, Wilkin DJ, Vos HL, Ortiz de Luna RI, Dehejia AM, Polymeropoulos MH, Francomano CA (May 1998). "Characterization of the human extracellular matrix protein 1 gene on chromosome 1q21". Matrix Biol. 16 (5): 289–92. doi:10.1016/S0945-053X(97)90017-2. PMID 9501329. 
  3. ^ a b "Entrez Gene: ECM1 extracellular matrix protein 1". 
  4. ^
  5. ^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology". 

Further reading[edit]