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Epithelial cell transforming 2
Protein ECT2 PDB 2cou.png
PDB rendering based on 2cou.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ECT2 ; ARHGEF31
External IDs OMIM600586 MGI95281 HomoloGene7298 GeneCards: ECT2 Gene
RNA expression pattern
PBB GE ECT2 gnf1h01477 at tn.png
PBB GE ECT2 gnf1h01478 s at tn.png
PBB GE ECT2 gnf1h08158 at tn.png
More reference expression data
Species Human Mouse
Entrez 1894 13605
Ensembl ENSG00000114346 ENSMUSG00000027699
UniProt Q9H8V3 Q07139
RefSeq (mRNA) NM_001258315 NM_001177625
RefSeq (protein) NP_001245244 NP_001171096
Location (UCSC) Chr 3:
172.47 – 172.54 Mb
Chr 3:
27.1 – 27.15 Mb
PubMed search [1] [2]

Protein ECT2 is a protein that in humans is encoded by the ECT2 gene.[1][2][3]


The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.[3]


ECT2 has been shown to interact with PARD6A.[4]


  1. ^ Miki T, Smith CL, Long JE, Eva A, Fleming TP (Apr 1993). "Oncogene ect2 is related to regulators of small GTP-binding proteins". Nature 362 (6419): 462–5. doi:10.1038/362462a0. PMID 8464478. 
  2. ^ Tatsumoto T, Xie X, Blumenthal R, Okamoto I, Miki T (Dec 1999). "Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis". J. Cell Biol. 147 (5): 921–8. doi:10.1083/jcb.147.5.921. PMC 2169345. PMID 10579713. 
  3. ^ a b "Entrez Gene: ECT2 epithelial cell transforming sequence 2 oncogene". 
  4. ^ Liu XF, Ishida H, Raziuddin R, Miki T (Aug 2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity". Mol. Cell. Biol. 24 (15): 6665–75. doi:10.1128/MCB.24.15.6665-6675.2004. PMC 444862. PMID 15254234. 

Further reading[edit]