4-hydroxyphenylacetate decarboxylase

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4-hydroxyphenylacetate decarboxylase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 4-hydroxyphenylacetate decarboxylase (EC is an enzyme that catalyzes the chemical reaction

(4-hydroxyphenyl)acetate + H+ \rightleftharpoons 4-methylphenol + CO2

Thus, the two substrates of this enzyme are 4-hydroxyphenylacetate and H+, whereas its two products are 4-methylphenol and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming). Other names in common use include p-hydroxyphenylacetate decarboxylase, p-Hpd, 4-Hpd, and 4-hydroxyphenylacetate carboxy-lyase.


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