4-hydroxyphenylacetate decarboxylase

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4-hydroxyphenylacetate decarboxylase
Identifiers
EC number 4.1.1.83
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 4-hydroxyphenylacetate decarboxylase (EC 4.1.1.83) is an enzyme that catalyzes the chemical reaction

(4-hydroxyphenyl)acetate + H+ \rightleftharpoons 4-methylphenol + CO2

Thus, the two substrates of this enzyme are 4-hydroxyphenylacetate and H+, whereas its two products are 4-methylphenol and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming). Other names in common use include p-hydroxyphenylacetate decarboxylase, p-Hpd, 4-Hpd, and 4-hydroxyphenylacetate carboxy-lyase.

References[edit]

  • D'Ari L, Barker HA (1985). "p-Cresol formation by cell-free extracts of Clostridium difficile". Arch. Microbiol. 143 (3): 311–2. doi:10.1007/BF00411256. PMID 3938267. 
  • Selmer T, Andrei PI (2001). "p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol". Eur. J. Biochem. 268 (5): 1363–72. doi:10.1046/j.1432-1327.2001.02001.x. PMID 11231288. 
  • Andrei PI, Pierik AJ, Zauner S, Andrei-Selmer LC, Selmer T (2004). "Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase. A small subunit, HpdC, is essential for catalytic activity". Eur. J. Biochem. 271 (11): 2225–30. doi:10.1111/j.1432-1033.2004.04152.x. PMID 15153112.