EDC3

Enhancer of mRNA decapping 3 homolog (S. cerevisiae)
Rendering based on PDB 2VC8.
Available structures PDB 2VC8, 2WAX, 2WAY, 3D3J, 3D3K
Identifiers
Symbols	EDC3; FLJ21128; FLJ31777; LSM16; YJDC; YJEFN2
External IDs	OMIM: 609842 MGI: 2142951 HomoloGene: 11827 GeneCards: EDC3 Gene
Gene Ontology Molecular function • RNA binding • protein binding Cellular component • cytoplasmic mRNA processing body • cytoplasm • cytosol Biological process • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • RNA metabolic process • mRNA metabolic process • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80153	353190
Ensembl	ENSG00000179151	ENSMUSG00000038957
UniProt	Q96F86	A0ELI5
RefSeq (mRNA)	NM_001142443.1	NM_153799.3
RefSeq (protein)	NP_001135915.1	NP_722494.1
Location (UCSC)	Chr 15: 74.92 – 74.99 Mb	Chr 9: 57.56 – 57.6 Mb
PubMed search	[1]	[2]

Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Jin J, Smith FD, Stark C et al (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wan D, Gong Y, Qin W et al (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524842. 
• Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (2006). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping". Mol. Cell 20 (6): 905–15. doi:10.1016/j.molcel.2005.10.031. PMID 16364915. 
• Beausoleil SA, Villén J, Gerber SA et al (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
• Ewing RM, Chu P, Elisma F et al (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 
• Tritschler F, Eulalio A, Truffault V et al (2007). "A Divergent Sm Fold in EDC3 Proteins Mediates DCP1 Binding and P-Body Targeting". Mol. Cell. Biol. 27 (24): 8600–11. doi:10.1128/MCB.01506-07. PMC 2169425. PMID 17923697. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2169425.